Impaired expression of GABA transporters in the human Alzheimer's disease hippocampus, subiculum, entorhinal cortex and superior temporal gyrus. (20th May 2017)

• Record Type: Journal Article
• Authors: Fuhrer, Tessa E.; Palpagama, Thulani H.; Waldvogel, Henry J.; Synek, Beth J.L.; Turner, Clinton; Faull, Richard L.; Kwakowsky, Andrea
• Is Part Of: Neuroscience. Volume 351(2017)
• Page Start: 108
• Page End: 118
• Publication Date: 2017-05-20
• Subjects: AD Alzheimer's disease -- CERAD Consortium to Establish a Registry for Alzheimer's disease -- GABA Gamma-aminobutyric acid -- GAD glutamic acid decarboxylase -- GAT GABA transporter; GABA -- GABA transporters -- Alzheimer's disease -- human brain; Neurochemistry -- Periodicals; Neurophysiology -- Periodicals; Neurology -- Periodicals; Neurochimie -- Périodiques; Neurophysiologie -- Périodiques; Neurochemistry; Neurophysiology; Electronic journals; Periodicals; Electronic journals; 612.8
• DOI: 10.1016/j.neuroscience.2017.03.041
• Languages: English
• ISSNs: 0306-4522

Abstract

Highlights: Showed alterations in the expression of the GATs in the AD brain. The expression of the GATs shows brain-region-, cell-layer- and cell-type-specific alterations in AD. Complex activation pattern and possibly co-regulation of different GATs are proposed. Abstract: Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the brain and plays an important role in regulating neuronal excitability. GABA reuptake from the synapse is dependent on specific transporters – mainly GAT-1, GAT-3 and BGT-1 (GATs). This study is the first to show alterations in the expression of the GATs in the Alzheimer's disease (AD) hippocampus, entorhinal cortex and superior temporal gyrus. We found a significant increase in BGT-1 expression associated with AD in all layers of the dentate gyrus, in the stratum oriens of the CA2 and CA3 and the superior temporal gyrus. In AD there was a significant decrease in GAT-1 expression in the entorhinal cortex and superior temporal gyrus. We also found a significant decrease in GAT-3 immunoreactivity in the stratum pyramidale of the CA1 and CA3, the subiculum and entorhinal cortex. These observations indicate that the expression of the GATs shows brain-region- and layer-specific alterations in AD, suggesting a complex activation pattern of different GATs during the course of the disease.