Modes of invasion during tumour dissemination. Issue 1 (9th December 2016)

• Record Type: Journal Article
• Authors: Pandya, Pahini; Orgaz, Jose L.; Sanz‐Moreno, Victoria
• Is Part Of: Molecular oncology. Volume 11:Issue 1(2017)
• Page Start: 5
• Page End: 27
• Publication Date: 2016-12-09
• Subjects: actomyosin contractility -- cancer metastasis -- invasion -- plasticity -- Rho GTPases; Cancer -- Molecular aspects -- Periodicals; 616.994005
• DOI: 10.1002/1878-0261.12019
• Languages: English
• ISSNs: 1574-7891

Abstract

Abstract : Cancer cell migration and invasion underlie metastatic dissemination, one of the major problems in cancer. Tumour cells exhibit a striking variety of invasion strategies. Importantly, cancer cells can switch between invasion modes in order to cope with challenging environments. This ability to switch migratory modes or plasticity highlights the challenges behind antimetastasis therapy design. In this Review, we present current knowledge on different tumour invasion strategies, the determinants controlling plasticity and arising therapeutic opportunities. We propose that targeting master regulators controlling plasticity is needed to hinder tumour dissemination and metastasis. Abstract : This Review gives an overview of cell migration mechanisms and describes the different individual and collective modes of invasion, the plasticity that enables cancer cells to switch between modes, and the determinants of this plasticity. Therapeutic challenges arising from migratory plasticity and the potential targets that could block completely cancer cell invasion are also discussed.