Effects of argon plasma coagulation on human stomach tissue: An ex vivo study. Issue 5 (27th April 2017)

• Record Type: Journal Article
• Authors: Gong, Eun Jeong; Ahn, Ji Yong; Jung, Hwoon‐Yong; Park, Young Soo; Na, Hee Kyong; Jung, Kee Wook; Kim, Do Hoon; Lee, Jeong Hoon; Choi, Kee Don; Song, Ho June; Lee, Gin Hyug; Kim, Jin‐Ho
• Is Part Of: Journal of gastroenterology and hepatology. Volume 32:Issue 5(2017)
• Page Start: 1040
• Page End: 1045
• Publication Date: 2017-04-27
• Subjects: ablation techniques -- argon plasma coagulation -- gastric neoplasm; Gastroenterology -- Periodicals; Digestive organs -- Diseases -- Periodicals; Liver -- Diseases -- Periodicals; Gastroenterology -- Periodicals; Liver Diseases -- Periodicals; 616.33
• DOI: 10.1111/jgh.13636
• Languages: English
• ISSNs: 0815-9319

Abstract

Abstract: Background and Aim: Argon plasma coagulation (APC) is a safe alternative treatment for gastrointestinal neoplasms and precancerous lesions. However, the extent of thermal damage after APC is difficult to predict. We investigated the effects of APC on human stomach tissue. Methods: Argon plasma coagulation was performed on 10 freshly resected human stomachs that were obtained after total gastrectomy. The effects on tissue were compared across power settings (40, 60, and 80 W), durations (5, 10, 15, 20, and 25 s), and between injection (submucosal injection of normal saline) and control (without injection) groups. Success was defined as complete mucosal necrosis without damaging the muscularis propria. Results: Without submucosal injection, the incidence of damaging the muscularis propria increased as the power and duration increased. Tissue damage in the injection group was mostly confined to the submucosa, even when using the high‐power setting. In the injection group, ablations at 40 W for 20 s, 60 W for 15 s, and 80 W for 15 or 20 s produced success rates ≥80%. In the control group, ablations at 60 W for 10 s, and 80 W for 5, or 10 s produced success rates ≥80%. The optimal energy levels to achieve complete mucosal and submucosal necrosis without damaging the muscularis propria were 800–1600 and 600–800 J in the injection and control groups, respectively. Conclusion: Application of APC produces good results with a low risk of perforation.