Fluorescent Imaging‐Guided Chemotherapy‐and‐Photodynamic Dual Therapy with Nanoscale Porphyrin Metal–Organic Framework. Issue 17 (28th February 2017)

• Record Type: Journal Article
• Authors: Liu, Wei; Wang, Yong‐Mei; Li, Yu‐Hao; Cai, Shi‐Jiao; Yin, Xue‐Bo; He, Xi‐Wen; Zhang, Yu‐Kui
• Is Part Of: Small. Volume 13:Issue 17(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-02-28
• Subjects: chemotherapy -- imaging‐guided therapy -- photodynamic therapy -- porphyrin metal–organic framework; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.201603459
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract : Imaging‐guided therapy systems (IGTSs) are revolutionary techniques used in cancer treatment due to their safety and efficiency. IGTSs should have tunable compositions for bioimaging, a suitable size and shape for biotransfer, sufficient channels and/or pores for drug loading, and intrinsic biocompatibility. Here, a biocompatible nanoscale zirconium‐porphyrin metal–organic framework (NPMOF)‐based IGTS that is prepared using a microemulsion strategy and carefully tuned reaction conditions is reported. A high content of porphyrin (59.8%) allows the achievement of efficient fluorescent imaging and photodynamic therapy (PDT). The 1D channel of the Kagome topology of NPMOFs provides a 109% doxorubicin loading and pH‐response smart release for chemotherapy. The fluorescence guiding of the chemotherapy‐and‐PDT dual system is confirmed by the concentration of NPMOFs at cancer sites after irradiation with a laser and doxorubicin release, while low toxicity is observed in normal tissues. NPMOFs are established as a promising platform for the early diagnosis of cancer and initial therapy. Abstract : Biocompatible nanoporphyrin metal–organic framework (NPMOF) built from a porphyrin and Zr exhibits excellent drug adsorption, photodynamic therapy efficiency, and fluorescent imaging property. The integrity of these capabilities into a single platform makes NPMOF advantageous to offer fluorescent imaging‐guided chemotherapy‐and‐photodynamic dual‐therapy. This fresh model makes cancer treating more efficient and safe.