Simultaneous detection of sulfoxaflor and its metabolites, X11719474 and X11721061, in lettuce using a modified QuEChERS extraction method and liquid chromatography–tandem mass spectrometry. (19th December 2016)

• Record Type: Journal Article
• Authors: Kim, Sung‐Woo; Rahman, Md. Musfiqur; Abd El‐Aty, A. M.; Kabir, Md. Humayun; Na, Tae Woong; Choi, Jeong‐Heui; Shin, Ho‐Chul; Shim, Jae‐Han
• Is Part Of: Biomedical chromatography. Volume 31:Number 6(2017:Jun.)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2016-12-19
• Subjects: half‐life -- lettuce -- liquid chromatography–tandem mass spectrometry -- QuEChERS -- residues -- sulfoxaflor, metabolites; Chromatographic analysis -- Periodicals; Biology -- Periodicals; Medicine -- Periodicals; Biology -- Periodicals; Chromatography -- methods -- Periodicals; Medicine -- Periodicals; 543.089
• DOI: 10.1002/bmc.3885
• Languages: English
• ISSNs: 0269-3879

Abstract

Abstract: An analytical method has been developed to quantify the residual levels of sulfoxaflor and its metabolites (X11719474 and X11721061) in/on cultivated lettuce grown under greenhouse conditions. Samples were extracted and purified using a quick, easy, cheap, effective, rugged, and safe 'QuEChERS' method (original version) following systematic method optimization and were analyzed by liquid chromatography–tandem mass spectrometry (LC–MS/MS). Good linearity with coefficient of determination ≥0.9930 was obtained and the limits of detection (LOD) and quantification (LOQ) were in the ranges of 0.003–0.006 and 0.01–0.02 mg/kg, respectively. The recovery rates of both the parent compound and its metabolites (fortified at 10 and 50× the LOQ) estimated from six replicates ranged between 81.9 and 115.5% with a relative standard deviation <12%. The validated method was applied to field‐incurred samples (collected over 7 days) sprayed once or twice with a water‐dispersible granule formulation. Notably, a substantial reduction in rate was observed after 3 days and the half‐life was short, only 1.5 days. The developed method is simple and versatile and can be used for various leafy vegetables.