Modelling osteoblast adhesion on surface-engineered biomaterials: optimisation of nanophase grain size. Issue 8 (11th June 2017)

• Record Type: Journal Article
• Authors: Chen, Song; Lee, Cheuk Y.; Li, Rachel W.; Smith, Paul N.; Qin, Qing H.
• Is Part Of: Computer methods in biomechanics and biomedical engineering. Volume 20:Issue 8(2017)
• Page Start: 905
• Page End: 914
• Publication Date: 2017-06-11
• Subjects: Mathematical model -- cell adhesion -- material surface -- osteoblast -- nanophase grain size; Biomechanics -- Data processing -- Periodicals; Biomedical engineering -- Periodicals; Biomechanics -- Periodicals; Biomedical Engineering -- methods -- Periodicals; Computing Methodologies -- Periodicals; 612.7
• DOI: 10.1080/10255842.2017.1314468
• Languages: English
• ISSNs: 1025-5842

Abstract

Abstract: A double-layered model is proposed for numerically simulating osteoblast adhesion on surface-engineered biomaterials. The proposed model consists of molecular and cellular motions based on theoretical and experimental evidence and creates predictive simulations from sparse experimental data. The comparison of numerical solutions and experimental data reveals that the proposed model can explain the nonlinear behaviour of osteoblast adhesion on material surfaces in respect to nanophase grain size (0–100 nm). The model further provides insight into the optimisation of nanophase grain size on the surface of the biomaterial.