Computational study of cell adhesion and rolling in flow channel by meshfree method. Issue 8 (11th June 2017)

• Record Type: Journal Article
• Authors: Lin, Liqiang; Zeng, Xiaowei
• Is Part Of: Computer methods in biomechanics and biomedical engineering. Volume 20:Issue 8(2017)
• Page Start: 832
• Page End: 841
• Publication Date: 2017-06-11
• Subjects: Cell tethering -- cell rolling -- meshfree method -- human monocyte -- shear flow -- numerical simulation; Biomechanics -- Data processing -- Periodicals; Biomedical engineering -- Periodicals; Biomechanics -- Periodicals; Biomedical Engineering -- methods -- Periodicals; Computing Methodologies -- Periodicals; 612.7
• DOI: 10.1080/10255842.2017.1303051
• Languages: English
• ISSNs: 1025-5842

Abstract

Abstract: Tethering and rolling of circulating leukocytes on the surface of endothelium are critical steps during an inflammatory response. A soft solid cell model was proposed to study monocytes tethering and rolling behaviors on substrate surface in shear flow. The interactions between monocytes and micro-channel surface were modeled by a coarse-grained molecular adhesive potential. The computational model was implemented in a Lagrange-type meshfree Galerkin formulation to investigate the monocyte tethering and rolling process with different flow rates. From the simulation results, it was found that the flow rate has profound effects on the rolling velocity, contact area and effective stress of monocytes. As the flow rate increased, the rolling velocity would increase linearly, whereas the contact area and average effective stress in monocyte showed nonlinear increase.