Humanin ameliorates diazepam-induced memory deficit in mice. (April 2017)

• Record Type: Journal Article
• Authors: Murakami, Minetaka; Nagahama, Masatoshi; Maruyama, Takuma; Niikura, Takako
• Is Part Of: Neuropeptides. Volume 62(2017)
• Page Start: 65
• Page End: 70
• Publication Date: 2017-04
• Subjects: Humanin -- Diazepam -- GABAergic -- Amnesia; Neuropeptides -- Periodicals; Neuropeptides; Neuropeptides -- Périodiques; Neuropeptides; Electronic journals; Periodicals; 572.65
• DOI: 10.1016/j.npep.2016.10.008
• Languages: English
• ISSNs: 0143-4179

Abstract

Abstract: Humanin (HN) is an endogenous 24-residue peptide. A highly potent HN derivative, S14G-HN, which has a substitution of serine 14 to glycine, reduced amyloid burden and suppressed cognitive impairment in a mouse model of Alzheimer's disease. S14G-HN also suppressed amnesia induced by a muscarinic receptor antagonist in rodents. To understand the effects of HN on brain function, we tested the effect of S14G-HN on diazepam (DZP)-induced memory impairment and anxiety in mice using the object recognition test and zero-maze test, respectively. Intraperitoneal injection of S14G-HN reversed the DZP-induced memory deficit, whereas no significant change was observed in behavioral markers of anxiety. S14G-HN had no effect on locomotor activity in either test, indicating that S14G-HN did not affect physical functioning or motivation. These results suggest that HN preferentially influences cognitive function but not emotional function in the central nervous system. Highlights: Humanin ameliorated object memory impairment induced by diazepam. Humanin did not alter diazepam-induced anti-anxiety effects. Locomotor activity and motivation were not affected by humanin. Intraperitoneal injection of humanin alone did not induce anti-anxiety effects in mice.