Central administration of neuropeptide Y differentially regulates monoamines and corticosterone in heat-exposed fed and fasted chicks. (April 2017)

• Record Type: Journal Article
• Authors: Bahry, Mohammad A.; Chowdhury, Vishwajit S.; Yang, Hui; Tran, Phuong V.; Do, Phong H.; Han, Guofeng; Ikeda, Hiromi; Cockrem, John F.; Furuse, Mitsuhiro
• Is Part Of: Neuropeptides. Volume 62(2017)
• Page Start: 93
• Page End: 100
• Publication Date: 2017-04
• Subjects: NPY -- Rectal temperature -- Food intake -- Monoamines -- Corticosterone -- Chicks; Neuropeptides -- Periodicals; Neuropeptides; Neuropeptides -- Périodiques; Neuropeptides; Electronic journals; Periodicals; 572.65
• DOI: 10.1016/j.npep.2016.11.008
• Languages: English
• ISSNs: 0143-4179

Abstract

Abstract: Recently, we demonstrated that brain neuropeptide Y (NPY) mRNA expression was increased in heat exposed chicks. However, the functions of brain NPY during heat stress are unknown. This study was conducted to investigate whether centrally administered NPY affects food intake, rectal temperature, monoamines, stress hormones and plasma metabolites in chicks under high ambient temperatures (HT). Five or six-day-old chicks were centrally injected with 0, 188 or 375 pmol of NPY and exposed to either HT (35 ± 1 °C) or a control thermoneutral temperature (CT; 30 ± 1 °C) for 3 h whilst fed or fasted. NPY increased food intake under both CT and HT. NPY reduced rectal temperature 1 and 2 h after central administration under CT, but not under HT. Interestingly, NPY decreased brain serotonin and norepinephrine concentrations in fed chicks, but increased concentrations of brain dopamine and its metabolites in fasted and fed chicks, respectively. Plasma epinephrine was decreased by NPY in fed chicks, but plasma concentrations of norepinephrine and epinephrine were increased significantly by NPY in fasted-heat exposed chicks. Furthermore, NPY significantly reduced plasma corticosterone concentrations in fasted chicks. Plasma glucose and triacylglycerol were increased by NPY in fed chicks, but triacylglycerol declined in fasted NPY-injected chicks. In conclusion, brain NPY may attenuate the reduction of food intake during heat stress and the increased brain NPY might be a potential regulator of the monoamines and corticosterone to modulate stress response in heat-exposed chicks. Highlights: NPY decreased rectal temperature in fasted chicks at thermoneutral temperatures. Orexigenic effect of NPY was appeared under high ambient temperatures. NPY increased brain dopamine and decreased plasma corticosterone in fasted chicks. NPY may regulate the stress response to minimize heat stress in chicks.