Multigenerational effects of two glucocorticoids (prednisolone and dexamethasone) on life-history parameters of crustacean Ceriodaphnia dubia (Cladocera). (June 2017)

• Record Type: Journal Article
• Authors: Bal, Navdeep; Kumar, Anupama; Du, Jun; Nugegoda, Dayanthi
• Is Part Of: Environmental pollution. Volume 225(2017)
• Page Start: 569
• Page End: 578
• Publication Date: 2017-06
• Subjects: Corticosteroids -- Invertebrates -- Multigenerational exposure -- Intrinsic population rate; Pollution -- Periodicals; Pollution -- Environmental aspects -- Periodicals; Environmental Pollution -- Periodicals; Pollution -- Périodiques; Pollution -- Aspect de l'environnement -- Périodiques; Pollution -- Effets physiologiques -- Périodiques; Pollution; Pollution -- Environmental aspects; Periodicals; Electronic journals; 363.73
• DOI: 10.1016/j.envpol.2017.03.024
• Languages: English
• ISSNs: 0269-7491

Abstract

Abstract: Synthetic glucocorticoids (GCs) such as dexamethasone (DEX) and prednisolone (PDS) have been used since the 1940s to cure inflammatory and auto-immune disorders. Their use has been linked to a host of deleterious effects in aquatic ecosystems such as osteoporosis in vertebrates, developmental impairments in molluscs and reduced fecundity and growth in cladocerans. Apart from these handful of studies, the effects of GCs on aquatic biota are largely unknown. The present study is a first of its kind aiming to assess the multi-generational exposure effects of DEX and PDS on the life history parameters of Ceriodaphnia dubia (C. dubia) . Multigenerational studies have proved to be an advantage in assessing the cumulative damage caused by aquatic toxicants at the population level of the exposed organisms over a period of successive generations using multiple biological endpoints. Test results demonstrated that C. dubia exhibited varied sensitivities towards both the studied chemicals however were more sensitive to DEX with 48-h EC50 (95% confidence interval) of 0.75 mg/L (CI: 0.59–0.92) in comparison to PDS [19 mg/L (CI: 15–23)]. EC10 values for F0 in a multigenerational chronic bioassays were 48 μg/L (CI: 37.4–61) for DEX and 460 μg/L (CI: 341–606) for PDS and in F3 were 2.2 μg/L (CI: 1.6–3.1) for DEX and 31 μg/L (CI: 19.4–46) for PDS. There was a positive trend of increased toxicity followed by reduced life history traits such as fecundity, brood size and time to first brood and intrinsic rate of population increase and body growth (length and area) of C. dubia in the case of both studied chemicals. The results from the current work highlighted the importance of multigenerational studies in identifying the evolutionary responses of stressed non-target aquatic organisms, and data obtained can be further used in developing water quality guidelines. Graphical abstract: Highlights: GC-induced toxicity affects life-history traits of C. dubia at their population level. Significance of multigenerational bioassays to detect responses of stressed species. C. dubia were more sensitive to DEX than PDS in all exposed generations. Increased toxicity effects in F3 generation than F0 in both test chemicals. Abstract : Capsule: The present research emphasised the significance of multigenerational studies in identifying the evolutionary responses of stressed aquatic organisms to continual exposure of GC chemicals, affecting them at their population level.