To each his own: isonitriles for all flavors. Functionalized isocyanides as valuable tools in organic synthesis. (16th December 2016)

• Record Type: Journal Article
• Authors: Giustiniano, Mariateresa; Basso, Andrea; Mercalli, Valentina; Massarotti, Alberto; Novellino, Ettore; Tron, Gian Cesare; Zhu, Jieping
• Is Part Of: Chemical Society reviews. Volume 46:Number 5(2017)
• Page Start: 1295
• Page End: 1357
• Publication Date: 2016-12-16
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c6cs00444j
• Languages: English
• ISSNs: 0306-0012

Abstract

Abstract : This review provides a comprehensive overview on the preparation and synthetic applications of functionalized isocyanides. Abstract : The term functionalized isocyanides refers to all those isocyanides in which a neighbouring functional group can finely tune the reactivity of the isocyano group or can be exploited in post-functionalization processes. In this manuscript, we have reviewed all the isocyanides in which the pendant functional group causes either deviation from or reinforces the normal reactivity of the isocyano group and categorized them to highlight their common features and differences. An analysis of their synthetic potential and the possible unexplored directions for future research studies is also addressed.