Adoptive immunotherapy for cancer. Issue 1 (January 2014)

• Record Type: Journal Article
• Authors: Ruella, Marco; Kalos, Michael
• Is Part Of: Immunological reviews. Volume 257:Issue 1(2014:Jan.)
• Page Start: 14
• Page End: 38
• Publication Date: 2014-01
• Subjects: adoptive cell therapy -- immunotherapy -- chimeric antigen receptor -- cancer -- immune modulation -- tumor microenvironment; Immunology -- Periodicals; Transplantation of organs, tissues, etc -- Periodicals; 616.079
• DOI: 10.1111/imr.12136
• Languages: English
• ISSNs: 0105-2896

Abstract

Summary: Recent clinical success has underscored the potential for immunotherapy based on the adoptive cell transfer (ACT) of engineered T lymphocytes to mediate dramatic, potent, and durable clinical responses. This success has led to the broader evaluation of engineered T‐lymphocyte‐based adoptive cell therapy to treat a broad range of malignancies. In this review, we summarize concepts, successes, and challenges for the broader development of this promising field, focusing principally on lessons gleaned from immunological principles and clinical thought. We present ACT in the context of integrating T‐cell and tumor biology and the broader systemic immune response. Video podcast available: Go to www.immunologicalreviews.com to watch an interview with Guest Editor Dr Carl June.