Cause of Death and Predictors of All‐Cause Mortality in Anticoagulated Patients With Nonvalvular Atrial Fibrillation: Data From ROCKET AF. Issue 3 (March 2016)

• Record Type: Journal Article
• Authors: Pokorney, Sean D.; Piccini, Jonathan P.; Stevens, Susanna R.; Patel, Manesh R.; Pieper, Karen S.; Halperin, Jonathan L.; Breithardt, Günter; Singer, Daniel E.; Hankey, Graeme J.; Hacke, Werner; Becker, Richard C.; Berkowitz, Scott D.; Nessel, Christopher C.; Mahaffey, Kenneth W.; Fox, Keith A. A.; Califf, Robert M.
• Other Names: Anderson J. investigator.; Bedwell N. investigator.; Bilsker M. investigator.; Bruce G. investigator.; Agah R. investigator.; DeSantis M. investigator.; Eisenberg S. investigator.; Flores A. investigator.; Herzog W. investigator.; Klein S. investigator.; Snyder H. investigator.; Krueger S. investigator.; Almaguer E. investigator.; Lavie E. investigator.; Lee C. investigator.; Mallis G. investigator.; Modi M. investigator.; Woodworth G. investigator.; Niazi I. investigator.; Peart B. investigator.; Sundaram S. investigator.; Snoddy B. investigator.; Sotolongo R. investigator.; Moloney J. investigator.; Vijayaraghavan K. investigator.; Whittier F. investigator.; Yellen L. investigator.; Banerjee S. investigator.; Lustgarten D. investigator.; Suresh D. investigator.; Gelernt M. investigator.; Levinson L. investigator.; Ghanekar R. investigator.; Kneller G. investigator.; Hall C. investigator.; Fadl Y. investigator.; Pirwitz M. investigator.; French W. investigator.; Mayer N. investigator.; Pugeda J. investigator.; Steel K. investigator.; Mody F. investigator.; Malik A. investigator.; Chandna H. investigator.; Go A. investigator.; Emlein G. investigator.; Bowden W. investigator.; Moscoso R. investigator.; Hodson R. investigator.; Berk M. investigator.; Pan D. investigator.; Pappas J. investigator.; Orchard R. investigator.; Lynchard G. investigator.; Vijay N. investigator.; Khan W. investigator.; El Khadra M investigator.; Antonishen M. investigator.; Cucher F. investigator.; Staab M. investigator.; Zebrack J. investigator.; Borromeo S investigator.; Heilman J. investigator.; Chaturvedi S. investigator.; Makam S. investigator.; Turk S. investigator.; Hyers T. investigator.; Williams G. investigator.; Labroo A. investigator.; Gill S. investigator.; Myears D. investigator.; Weinstein J. investigator.; Shanes J. investigator.; Chandrashekhar Y. investigator.; Shah S. investigator.; Reiter W. investigator.; Logemann T. investigator.; Almquist A. investigator.; Bhagwat R. investigator.; Tak T. investigator.; Shen‐Ling J. investigator.; Patel P. investigator.; Artis A. investigator.; Arouni A. investigator.; Lauer M. investigator.; Kinney K. investigator.; Elsen J. investigator.; Roan P. investigator.; Villafria R. investigator.; Sumpter M. investigator.; Ip J. investigator.; Welka S. investigator.; Schifferdecker B. investigator.; Sandoval R. investigator.; Speirs S. investigator.; Jones A. investigator.; Haldis T. investigator.; Kazmierski J. investigator.; Sutherland J. investigator.; Dietrich D. investigator.; Telfer E. investigator.; Berry J. investigator.; McElveen A. investigator.; Russell J. investigator.; Sackett M. investigator.; Antonios N. investigator.; Smith D. investigator.; Vora K. investigator.; Kirby A. investigator.; Lui H. investigator.; Mego D. investigator.; Ziada K. investigator.; Navas J. investigator.; Taussig A. investigator.; Koren M. investigator.; Vogel C. investigator.; Saba F. investigator.; Parrott C. investigator.; Schneider R. investigator.; Shirwany A. investigator.; Rubin M. investigator.; Treasure C investigator.; Bertolet B. investigator.; Chang M. investigator.; Langberg J. investigator.; Becker R. investigator.; Cohen Y. investigator.; McGrew F. investigator.; White J. investigator.; Arzola F. investigator.; Zelenka J. investigator.; Tannenbaum A. investigator.; Fernandes V. investigator.; Jamnadas P. investigator.; Agamasu J. investigator.; Collins B. investigator.; Jauch W. investigator.; Sasseen B. investigator.; Hotchkiss D. investigator.; Abadier R. investigator.; Osunkoya A. investigator.; Schlau A. investigator.; Chappel C. investigator.; Foster M. investigator.; Braun E. investigator.; Mostel E. investigator.; Capo J. investigator.; Ashchi M. investigator.; Howard V. investigator.; Albirini A. investigator.; Burger A. investigator.; Rolston D. investigator.; Staniloae C. investigator.; Bacon J. investigator.; Wiseman A. investigator.; McGarvey J investigator.; Sonel A. investigator.; Hamroff G. investigator.; Chang D. investigator.; Daboul N. investigator.; Broderick G. investigator.; Meholick A. investigator.; Corbelli J. investigator.; Silverman R. investigator.; Raffetto J. investigator.; Fishberg R. investigator.; Georgeson S. investigator.; Held J. investigator.; Seidner M. investigator.; Saint‐Jacques H. investigator.; Heitner J. investigator.; Kutalek S. investigator.; Friedlander I. investigator.; Hutchinson B. investigator.; Walia J. investigator.; Kondo N. investigator.; Smiley N. investigator.; Blitz L. investigator.; Dale H. investigator.; Sulman S. investigator.; Szulawski I. investigator.; Modares F. investigator.; Martin R. investigator.; Nahhas A. investigator.; Renzi M. investigator.; Akyea‐Djamson A. investigator.; Alfieri A. investigator.; Sandhu J. investigator.; Voyce S. investigator.; Amaram S. investigator.; Meyerrose G. investigator.; Shoukfeh M. investigator.; Lee F. investigator.; Villegas B. investigator.; Idowu O. investigator.; Khera A. investigator.; Sam C. investigator.; Vo A. investigator.; Lieber I. investigator.; Smith T. investigator.; Awan N. investigator.; Tsai C. investigator.; Ganim R. investigator.; Alzaghrini G. investigator.; Pitt W. investigator.; Shepherd A. investigator.; Tang S. investigator.; Stoltz S. investigator.; Nelson W. investigator.; Cox S. investigator.; Meymandi S. investigator.; Melucci M. investigator.; Thomas G. investigator.; Gogia H. investigator.; Machell C. investigator.; Chandrasekaran S. investigator.; Brown C. investigator.; Jetty P. investigator.; Miller G. investigator.; Dykstra G. investigator.; Jaffrani N. investigator.; Zakhary B. investigator.; Caruso A. investigator.; Zolty R. investigator.; Fox D. investigator.; Jacobs G. investigator.; Lebenthal M. investigator.; Mukherjee S. investigator.; Zimetbaum P. investigator.; Kingsley J. investigator.; Jones R. investigator.; Robinson V. investigator.; Kenton D. investigator.; Usedom J. investigator.; Williams S. investigator.; Snipes C. investigator.; Wilson V. investigator.; Hasty R. investigator.; Shoemaker J. investigator.; Donahue M. investigator.; Al‐Saghir Y. investigator.; Thomsen E. investigator.; Yarows S. investigator.; Chastain S. investigator.; McLaughlin P. investigator.; Wakham M. investigator.; Shrestha D. investigator.; Simmons J. investigator.; Fisher D. investigator.; Seymour Z. investigator.; Frandsen B. investigator.; First B. investigator.; Sharpe C. investigator.; Popeil L. investigator.; Guthrie R. investigator.; Hunter J. investigator.; Alvarado O. investigator.; Sandberg J. investigator.; Gutman N. investigator.; Belber A. investigator.; Arkhipov M. investigator.; Ballyzek M. investigator.; Baranov A. investigator.; Barbarash O. investigator.; Barbarich V. investigator.; Belenky D. investigator.; Berkovich O. investigator.; Bokarev I. investigator.; Boyarkin M. investigator.; Vaniev S. investigator.; Volkova E. investigator.; Gratsiansky N. investigator.; Demin A. investigator.; Zadionchenko V. investigator.; Zateyshchikov D. investigator.; Zrazhevsky K. investigator.; Mazaev V. investigator.; Martynov A. investigator.; Mikhailov S. investigator.; Mkrtchian V. investigator.; Novozhenov V. investigator.; Raskina T. investigator.; Rebrov A. investigator.; Sanina N. investigator.; Simanekov V. investigator.; Sitnikova M. investigator.; Smolenskaya O. investigator.; Stryuk R. investigator.; Storozhakov G. investigator.; Tankhilevich B. investigator.; Tereschenko S. investigator.; Khokhlov A. investigator.; Khrustalev O. investigator.; Chernov S. investigator.; Shvarts Y. investigator.; Shubik Y. investigator.; Shulman V. investigator.; Yakushin S. investigator.; Bugrova O. investigator.; Ivleva A. investigator.; Libis R. investigator.; Khozyainova N. investigator.; Maslov S. investigator.; Baranova E. investigator.; Sherenkov A. investigator.; Libov I. investigator.; Lusov V. investigator.; Chumakova G. investigator.; Kuznetsov V. investigator.; Ryamzina I. investigator.; Reshetko O. investigator.; Boldueva S. investigator.; Alekseeva N. investigator.; Novikova T. investigator.; Dvornikov V. investigator.; Idrisova E. investigator.; Shostak N. investigator.; Yarokhno N. investigator.; Tebloev K. investigator.; Treshkur T. investigator.; Mazurov V. investigator.; Loktin E. investigator.; Sedavnyh I. investigator.; Alexeeva O. investigator.; Yakhontova P. investigator.; Repin A. investigator.; Izmozherova N. investigator.; Kostenko V. investigator.; Fokin A. investigator.; Ketova G. investigator.; Kouz S. investigator.; Leader R. investigator.; Ayala‐Paredes F. investigator.; Luton R. investigator.; Ma P. investigator.; Pandey S. investigator.; Pesant Y. investigator.; Senior R. investigator.; Vertes G. investigator.; Bell A. investigator.; Crowley D. investigator.; Vizel S. investigator.; Lasko B. investigator.; Landry D. investigator.; Berger L. investigator.; Heath J. investigator.; Bessoudo R. investigator.; Ling M. investigator.; Tellier G. investigator.; Berlingieri J. investigator.; Kafka H. investigator.; Hill L. investigator.; Mazza G. investigator.; O'Mahony W. investigator.; Chilvers M. investigator.; O'Mahony M. investigator.; Newman D. investigator.; Silagy S. investigator.; Heffernan M. investigator.; Bennett M. investigator.; Bhesania T. investigator.; Rockman G. investigator.; Ng K. investigator.; Kalra B. investigator.; Meneses G. investigator.; Liang W. investigator.; Cheung M. investigator.; Kozak J. investigator.; Pugen G. investigator.; Vavougios J. investigator.; Kates M. investigator.; Nunes‐Vaz C. investigator.; Jaffer S. investigator.; Orfi J. investigator.; Faiers A. investigator.; Chung C. investigator.; Felsen S. investigator.; Bergman S. investigator.; Bernstein I. investigator.; Brownscombe L. investigator.; Stockdill J. investigator.; Silver E. investigator.; Ezekiel D. investigator.; Jagan N. investigator.; Khurana M. investigator.; Reisler H. investigator.; Goldman H. investigator.; Maung T. investigator.; Wong F. investigator.; Gillis G. investigator.; Vexler R. investigator.; Goldberg B. investigator.; Luterman M. investigator.; Gould D. investigator.; Coutu B. investigator.; Ouellet A. investigator.; MacDonald P. investigator.; Jones M. investigator.; Collette R. investigator.; Chong P. investigator.; Fargher T. investigator.; St‐Maurice F. investigator.; Fortin C. investigator.; Chehayeb R. investigator.; Proulx G. investigator.; Roy R. investigator.; Liutkus J. investigator.; Syan G. investigator.; Rupka D. investigator.; Lichtenstein T. investigator.; Kooy J. investigator.; Papastergiou D. investigator.; Lubelsky B. investigator.; Doyle W. investigator.; Rajakumar A. investigator.; Cha J. investigator.; Choudhry A. investigator.; Bhamjee H. investigator.; Mawji A. investigator.; Durfresne M. investigator.; Constance C. investigator.; Mutrie J. investigator.; Najarali A. investigator.; Warren R. investigator.; Mucha M. investigator.; Borts D. investigator.; Nord P. investigator.; Carrier S. investigator.; Dawood M. investigator.; Sabe‐Affaki G. investigator.; Archibald J. investigator.; Abram N. investigator.; Teitelbaum E. investigator.; Ebrahim I. investigator.; Siebert R. investigator.; van Zyl L. investigator.; Theron H. investigator.; Lloyd E. investigator.; Sommers R. investigator.; Podgorski G. investigator.; Steingo L. investigator.; Dalby A. investigator.; Bayat J. investigator.; Herbst L. investigator.; Bester F. investigator.; Corbett C. investigator.; Bennett J. investigator.; Roodt A. investigator.; Roux J. investigator.; Abelson M. investigator.; Mohamed Z. investigator.; Nortje H. investigator.; Da Silva A. investigator.; Nikolaides K. investigator.; Liagkas K. investigator.; Papasteriadis E. investigator.; Achimastos A. investigator.; Koliopoulos N. investigator.; Trikas A. investigator.; Manolis A. investigator.; Ruiter J. investigator.; Basart D. investigator.; Crijns H. investigator.; Withagen A. investigator.; Janssen M. investigator.; Van Langeveld R investigator.; van Gelder I. investigator.; Hamer B. investigator.; Van Der Heijden R investigator.; Hertzeberger D. investigator.; Van Hessen M investigator.; Pieterse M. investigator.; Groutars R. investigator.; Kuijper A. investigator.; De Ruiter G investigator.; van Boven A. investigator.; Hoogslag P. investigator.; Kragten H. investigator.; Thijssen H. investigator.; Veldkamp R. investigator.; Scavee C. investigator.; Heidbuchel H. investigator.; Debruyne P. investigator.; Deruyter B. investigator.; El Ali H investigator.; Goethals M. investigator.; Cytryn R. investigator.; Striekwold H. investigator.; De Wolf L investigator.; Goethals P. investigator.; Provenier F. investigator.; Hellemans S. investigator.; Galinier M. investigator.; Coisne D. investigator.; Koenig A. investigator.; Galley D. investigator.; Destrac S. investigator.; Leduc J. investigator.; Rifai A. investigator.; Citron B. investigator.; Ellie E. investigator.; Fournier P. investigator.; Steg G. investigator.; Landel R. investigator.; Robinson A. investigator.; Ziegler F. investigator.; Boulliat J. investigator.; Zuber M. investigator.; Vida M. investigator.; Galve Basilio E. investigator.; Lopez M. investigator.; Íñiguez C. investigator.; Iglesias Alonso L. investigator.; Cavero Gibanel M. investigator.; Olivan Martinez J. investigator.; Calvo Iglesias F. investigator.; Marco Vera P. investigator.; Bruguera Cortada J. investigator.; Jaber Houbani A. investigator.; Merino J. investigator.; Olaz Preciado F. investigator.; Balaguer J. investigator.; de la Hera Galarza J investigator.; Martinez Rubio A. investigator.; Fontcuberta J. investigator.; Sotillo Marti J. investigator.; Gonzalez Juanatey J. investigator.; Del Campo R. investigator.; Vivanco G. investigator.; Alvarez Garcia P. investigator.; Pelayo M. investigator.; Lippai J. investigator.; Zamolyi K. investigator.; Károly T. investigator.; Vertes A. investigator.; Nagy A. investigator.; Kosa I. investigator.; Janosi A. investigator.; Lupkovics G. investigator.; Kalo E. investigator.; Forster T. investigator.; Kis E. investigator.; Tenczer J. investigator.; Bereczki D. investigator.; Komoly S. investigator.; Csanyi A. investigator.; Kiss R. investigator.; Valikovics A. investigator.; Dioszeghy P. investigator.; Masini F. investigator.; Terrosu P. investigator.; Cirrincione V. investigator.; Marabotti C. investigator.; Cosmi F. investigator.; Salvioni A. investigator.; Binetti G. investigator.; Piovaccari G. investigator.; Nassiacos D. investigator.; Boriani G. investigator.; Calvi V. investigator.; De Caterina R investigator.; Pengo V. investigator.; Parati G. investigator.; Carolei A. investigator.; D'Angelo A. investigator.; Di Biase M. investigator.; Fattore L. investigator.; Agnelli G. investigator.; Merlini P. investigator.; Furlan M. investigator.; Rasura M. investigator.; Gandolfo C. investigator.; Ageno W. investigator.; Piovella F. investigator.; Micieli G. investigator.; Cinteza M. investigator.; Fierbinteanu C. investigator.; Natase‐Melicovici D. investigator.; Ionescu D. investigator.; Macarie C. investigator.; Nanea I. investigator.; Radoi M. investigator.; Tatu‐Chitoiu G. investigator.; Dragulescu S. investigator.; Tudose A. investigator.; Militaru C. investigator.; Bengus C. investigator.; Ungureanu G. investigator.; Tau A. investigator.; Popa V. investigator.; Pirvu O. investigator.; Bojinca M. investigator.; Sipciu D. investigator.; Popescu M. investigator.; Chiru M. investigator.; Vinereanu D. investigator.; Tudoran M. investigator.; Cojocaru T. investigator.; Vintila M. investigator.; Aron G. investigator.; Petrascu O. investigator.; Bolohan F. investigator.; Baumgartner R. investigator.; Sekoranja L. investigator.; Vojacek J. investigator.; Lacnak B. investigator.; Kellnerova I. investigator.; Dunaj M. investigator.; Cihalik C. investigator.; Janota T. investigator.; Janousek J. investigator.; Bouchal P. investigator.; Spacek R. investigator.; Choi Siruckova J. investigator.; Heinc P. investigator.; Vojtisek P. investigator.; Pirchala M. investigator.; Malecha J. investigator.; Padour F. investigator.; Linhart A. investigator.; Mandysova E. investigator.; Jandik J. investigator.; Zidkova E. investigator.; Sipula D. investigator.; Ostadal P. investigator.; Polasek R. investigator.; Stransky V. investigator.; Marcinek G. investigator.; Rysava D. investigator.; Osmancik P. investigator.; Huber K. investigator.; Drexel H. investigator.; Brainin M. investigator.; Eichinger‐Hasenauer S. investigator.; Lang W. investigator.; Pilger E. investigator.; Moriarty A. investigator.; Hudson I. investigator.; Tang K. investigator.; Cleland J. investigator.; MacWalter R. investigator.; Cooke J. investigator.; McInnes G. investigator.; Durairaj R. investigator.; MacLeod M. investigator.; Murdoch D. investigator.; Kadr H. investigator.; Lip G. investigator.; Andrews R. investigator.; Hunt B. investigator.; Jackson P. investigator.; Roffe C. investigator.; Syed H. investigator.; Bath P. investigator.; Coyle J. investigator.; Kelly D. investigator.; Stender S. investigator.; TorpPedersen C. investigator.; Tuxen C. investigator.; Jensen G. investigator.; Melchior T. investigator.; Klarlund K. investigator.; Dahlstrom C. investigator.; Nielsen T. investigator.; Nielsen E. investigator.; Bronnum‐Schou J. investigator.; Sykulski R. investigator.; Blomstrom P. investigator.; Lindholm C. investigator.; Wallen T. investigator.; Nilsson C. investigator.; Bertholds E. investigator.; Carlsater J. investigator.; Sirnes P. investigator.; Elle S. investigator.; Risberg K. investigator.; Furuseth K. investigator.; Skag A. investigator.; Hoivik H. investigator.; Landmark N. investigator.; Kjaernli T. investigator.; Berg‐Johansen J. investigator.; Gradek G. investigator.; Drzewiecki A. investigator.; Pluta W. investigator.; Szwed H. investigator.; Trusz‐Gluza M. investigator.; Ogorek M. investigator.; Loboz‐Grudzien K. investigator.; Ruszkowski P. investigator.; Sciborski R. investigator.; Kopaczewski J. investigator.; Jaworska K. investigator.; Kubica J. investigator.; Opolski G. investigator.; Hoffman A. investigator.; Krzciuk M. investigator.; Sinkiewicz W. investigator.; Piotrowski W. investigator.; Kolodziej P. investigator.; Goszczynska M. investigator.; Rynkiewicz A. investigator.; Chojnowska L. investigator.; Lewczuk J. investigator.; Biedrzycka M. investigator.; Piepiorka M. investigator.; Kowal J. investigator.; Karczmarczyk A. investigator.; Pruszczyk P. investigator.; Tendera M. investigator.; Gaciong Z. investigator.; Krzeminska‐Pakula M. investigator.; Kornacewicz‐Jach Z. investigator.; Kania G. investigator.; Brachmann J. investigator.; Lawall H. investigator.; Guelker H. investigator.; Spitzer S. investigator.; MoebiusWinkler S. investigator.; Dempfle C. investigator.; Bode C. investigator.; Darius H. investigator.; Genth‐Zotz S. investigator.; Sommer S. investigator.; Roehnisch J. investigator.; Strasser R. investigator.; Daenschel W. investigator.; Schwencke C. investigator.; vom Dahl J investigator.; Meuser M. investigator.; Behrens‐Spandau S. investigator.; Behrens‐Humbold S. investigator.; Muegge A. investigator.; Schoen N. investigator.; Grooterhorst P. investigator.; Ebert H. investigator.; Kraemer A. investigator.; Kohler B. investigator.; Taggeselle J. investigator.; Claus G. investigator.; Sarnighausen H. investigator.; Al‐Zoebi A. investigator.; Schroeder T. investigator.; Weissbrodt M. investigator.; Lange R. investigator.; Gabelmann M. investigator.; Kaeaeb S. investigator.; Doerr M. investigator.; Boscher D. investigator.; Bosch R. investigator.; Sonntag F. investigator.; Bauknecht C. investigator.; Omran H. investigator.; Leicht M. investigator.; Veltkamp R. investigator.; Hohensee H. investigator.; Dieckmann H. investigator.; Winkelmann B. investigator.; Bernhardt P. investigator.; Schnabel A. investigator.; Kadel C. investigator.; Proskynitopoulos N. investigator.; Seidl K. investigator.; Schellong S. investigator.; Rios C. investigator.; Guevara C. investigator.; Coloma R. investigator.; Torrejon H. investigator.; Parra Galvan J. investigator.; Drago Silva J. investigator.; Gallegos J. investigator.; Mendoza A. investigator.; Negron S. investigator.; Watanabe L. investigator.; Medina F. investigator.; Virgen Carrilo L. investigator.; Alvarez Lopez H. investigator.; Rodriguez I. investigator.; Leiva‐Pons J. investigator.; Baños Velasco A. investigator.; Villarreal‐Careaga J. investigator.; De los Rios M investigator.; Gamba M. investigator.; Llamas Esperon G. investigator.; Villeda E. investigator.; Ahuad Guerrero A. investigator.; Alvariqueta A. investigator.; Amuchastegui M. investigator.; Bluguermann J. investigator.; Caime G. investigator.; Cuneo C. investigator.; Gabito A. investigator.; Garcia Brasca D. investigator.; Hominal M. investigator.; Jure H. investigator.; Luquez H. investigator.; Montana O. investigator.; Piskorz D. investigator.; Listorti S. investigator.; Serra J. investigator.; Sessa H. investigator.; Varini S. investigator.; Vita N. investigator.; Aiub J. investigator.; MacKinnon I. investigator.; Chekherdemian S. investigator.; Castagnino J. investigator.; Cimbaro Canella J. investigator.; Sgammini H. investigator.; Escudero A. investigator.; Albina G. investigator.; Rapallo C. investigator.; Balparda C. investigator.; Chahin M. investigator.; Fuentealba V. investigator.; Riccitelli M. investigator.; Casabe J. investigator.; Lobo Marquez L. investigator.; Kevorkian R. investigator.; Cuadrado J. investigator.; Dran R. investigator.; Muntaner J. investigator.; Gonzalez M. investigator.; Cartasegna L. investigator.; Hasbani E. investigator.; Hrabar A. investigator.; Sanchez A. investigator.; Vogel D. investigator.; Hershson A. investigator.; Avezum A. investigator.; Jaber J. investigator.; Ernesto Leaes P. investigator.; Bozza A. investigator.; Lorga Filho A. investigator.; Pimentel Filho P. investigator.; Moura Jorge J. investigator.; Maia L. investigator.; Manenti E. investigator.; D'Aurea Mora R investigator.; de Souza Neto J investigator.; Precoma D. investigator.; Rabelo A. investigator.; Rocha J. investigator.; Rossi P. investigator.; Kerr Saraiva J. investigator.; Zimerman L. investigator.; Bodanese L. investigator.; Figueiredo E. investigator.; de Souza W. Sebba Barroso investigator.; Braga J. investigator.; Alessi S. investigator.; Gomes M. investigator.; Silva R. investigator.; Teixeira M. investigator.; Costa F. investigator.; Motta M. investigator.; Sobral Filho D. investigator.; Reis G. investigator.; Garbelini B investigator.; Zimmermann S. investigator.; Pereira Barretto A. investigator.; Dohmann H. investigator.; Barreto Filho J. investigator.; Ghorayeb N. investigator.; Borelli F. investigator.; Rossi dos Santos F. investigator.; Lopes Prudente M. investigator.; Vejar M. investigator.; Lanas F. investigator.; Del Pino R. investigator.; Potthoff S. investigator.; Charme G. investigator.; Aguirre A. investigator.; Saldana A. investigator.; Garces E. investigator.; Bunster L. investigator.; Figueroa H. investigator.; Olivares C. investigator.; Raffo C. investigator.; Vergara E. investigator.; Sepulveda P. investigator.; Jano G. investigator.; Morales Alvarado J. investigator.; Suarez R. investigator.; Urina M. investigator.; Perez G. investigator.; Quintero A. investigator.; Pava L. investigator.; Botero Lopez R. investigator.; Luengas C. investigator.; Hernandez E. investigator.; Sanchez D. investigator.; Poveda C. investigator.; Coronel J. investigator.; Beltran R. investigator.; Jaramillo C. investigator.; Pardo J. investigator.; Ponte Negretti C. investigator.; Isea J. investigator.; Vergara G. investigator.; Morr I. investigator.; Sim K. investigator.; Wan Ahmad W. investigator.; Yusof Z. investigator.; Rosman A. investigator.; Basri H investigator.; Thompson P. investigator.; Jeffery I. investigator.; Purnell P. investigator.; Roberts‐Thomson P. investigator.; Heddle W. investigator.; Waites J. investigator.; Walters D. investigator.; Amerena J. investigator.; Challa P. investigator.; Karrasch J. investigator.; Lowy A. investigator.; Fitzpatrick D. investigator.; Parsons M. investigator.; Phan T. investigator.; Bladin C. investigator.; Donnan G. investigator.; Aroney G. investigator.; Gerraty R. investigator.; Anderson C. investigator.; Blombery P. investigator.; Martin P. investigator.; Tissa Wijeratne K. investigator.; Cross D. investigator.; Crimmins D. investigator.; Packham D. investigator.; Jackson D. investigator.; Chua W. investigator.; Merino R. investigator.; Magno M. investigator.; Tirador L. investigator.; Batalla E. investigator.; Manalo C. investigator.; Uy N. investigator.; Ebo G. investigator.; Reyes E. investigator.; Bernan A. investigator.; Richards M. investigator.; Hart H. investigator.; Mann S. investigator.; Fisher R. investigator.; Stewart R. investigator.; Wilkins G. investigator.; Barber A. investigator.; Tan R. investigator.; Ong H. investigator.; Singh R. investigator.; Sukonthasarn A. investigator.; Tanomsup S. investigator.; Krittayaphong R. investigator.; Piamsomboon C. investigator.; Piyayotai D. investigator.; Sunsaneewitayakul B. investigator.; Baek S. investigator.; Seo H. investigator.; Rim S. investigator.; Kim C. investigator.; Kim K. investigator.; Ryu K. investigator.; Jo S. investigator.; Tahk S. investigator.; Lee H. investigator.; Kim Y. investigator.; Shin D. investigator.; Choi Y. investigator.; Chung N. investigator.; Namgung J. investigator.; Hong T. investigator.; Shin W. investigator.; Jin S. investigator.; Yan X. investigator.; Fu G. investigator.; Lu G. investigator.; Yang K. investigator.; Xu D. investigator.; Chen J. investigator.; Liu J. investigator.; Wu S. investigator.; Song J. investigator.; Liao Y. investigator.; Xu B. investigator.; Li Z. investigator.; Ma S. investigator.; Yin Y. investigator.; Zhao Y. investigator.; Hu D. investigator.; Ma C. investigator.; Ma J. investigator.; Sun J. investigator.; Li H. investigator.; Hong X. investigator.; Yu B. investigator.; Lu Q. investigator.; Yang J. investigator.; Wu Z. investigator.; Li Y. investigator.; Huang Y. investigator.; Wang Y. investigator.; Liu M. investigator.; Cheng Y. investigator.; Yang T. investigator.; Chen K. investigator.; Wang H. investigator.; Yuan Z. investigator.; Wang J. investigator.; Zeng Z. investigator.; Chen Y. investigator.; Yavuzgil O. investigator.; Kozan O. investigator.; Etemoglu M. investigator.; Diker E. investigator.; Belgi A. investigator.; Ceyhan C. investigator.; Cin V. investigator.; Yilmaz O. investigator.; Ata N. investigator.; Altunkeser B. investigator.; Agacdiken Agir A. investigator.; Karadede A. investigator.; Topsakal R. investigator.; Gulati R. investigator.; Madhavan A. investigator.; Jain S. investigator.; Oomman A. investigator.; Janorkar S. investigator.; Kumar P. investigator.; Madhukar Naik A. investigator.; Thacker H. investigator.; Rajasekhar V. investigator.; Reddy R. investigator.; Keshavamurthy C. investigator.; Jain P. investigator.; Gowdappa B. investigator.; Gadkari M. investigator.; Abhyankar A. investigator.; Ramesh Babu B. investigator.; Vydianathan P. investigator.; Sinha S. investigator.; Garg N. investigator.; Rao S. investigator.; Gautam P. investigator.; Chockalingam K. investigator.; Kumbla M. investigator.; Panwar R. investigator.; Banker D. investigator.; Kaste M. investigator.; Jäkälä P. investigator.; Roine R. investigator.; Mihov A. investigator.; Raev D. investigator.; Yordanova V. investigator.; Dimitrova S. investigator.; Benov H. investigator.; Tsanova V. investigator.; Kyolean M. investigator.; Marchev S. investigator.; Stoikov A. investigator.; Zdravkov N. investigator.; Ramshev K. investigator.; Krastev A. investigator.; Stamenova P. investigator.; Angelova I. investigator.; Pencheva G. investigator.; Grigorova V. investigator.; Petrauskiene B. investigator.; Skripkauskiene I. investigator.; Raugaliene R. investigator.; Norkiene S. investigator.; Mazutavicius R. investigator.; Kavoliuniene A. investigator.; Aidietiene S. investigator.; Aganauskiene J. investigator.; Dailydkiene A. investigator.; Marcinkeviciene J. investigator.; Grigoniene L. investigator.; Anusauskiene J. investigator.; Kavaliauskiene R. investigator.; Lizogub V. investigator.; Rudenko L. investigator.; Tseluyko V. investigator.; Voronkov L. investigator.; Sychov O. investigator.; Svyshchenko Y. investigator.; Sirenko Y. investigator.; Serkova V. investigator.; Seredyuk N. investigator.; Pertseva T. investigator.; Netyazhenko V. investigator.; Lishnevska V. investigator.; Kupchynska O. investigator.; Koval O. investigator.; Koshukova G. investigator.; Karpenko O. investigator.; Grishyna O. investigator.; Faynyk A. investigator.; Dzyak G. investigator.; Dyadyk O. investigator.; Yena L. investigator.; Volkov V. investigator.; Rudyk I. investigator.; Kopytsya M. investigator.; Kononenko L. investigator.; Amosova K. investigator.; Zhurba S. investigator.; Kazimirko V. investigator.; Iuzkiv I. investigator.; Shershnyova O. investigator.; Khomazyuk T. investigator.; Batushkin V. investigator.; Vykhovanyuk I. investigator.; Popik G. investigator.; Skrebkov V. investigator.; Skurtov A. investigator.; Mishchenko T. investigator.; Lytvynenko N. investigator.; Sokolova L. investigator.; Vatutin M. investigator.; Shved M. investigator.; Rebrov B. investigator.; Kadina L. investigator.; Vajda M. investigator.; Ursol G. investigator.; Zheleznyy V. investigator.; Vysochanska T. investigator.; Gozhenko A. investigator.; Fan K. investigator.; Ho D. investigator.; Tse H. investigator.; Yu C. investigator.; Wong L. investigator.; Yeh H. investigator.; Pai P. investigator.; Hsieh I. investigator.; Huang C. investigator.; Hsieh Y. investigator.; Yin W. investigator.; Tsai L. investigator.; Huang T. investigator.; Chen C. investigator.; Chiang F. investigator.; Ueng K. investigator.; Charng M. investigator.; Marmor A. investigator.; Katz A. investigator.; Butnaru A. investigator.; Lewis B. investigator.; Eldar M. investigator.; Rosenhack S. investigator.; Elias N. investigator.; Koifman B. investigator.; Shochat M. investigator.; Swissa M. investigator.; Zimlichman R. investigator.; Bental T. investigator.; Weiss A. investigator.; Ganam R. investigator.; Elias M. investigator.; Nseir W. investigator.; Oliven A. investigator.; Brenner B. investigator.; Dayan M. investigator.;
• Is Part Of: Journal of the American Heart Association. Volume 5:Issue 3(2016)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2016-03
• Subjects: atrial fibrillation -- mortality -- rivaroxaban -- stroke -- warfarin; Heart -- Diseases -- Periodicals; Cardiovascular system -- Diseases -- Periodicals; Cerebrovascular disease -- Periodicals; Cardiology -- Periodicals; 616.1
• DOI: 10.1161/JAHA.115.002197
• Languages: English
• ISSNs: 2047-9980

Abstract

Abstract : Background: Atrial fibrillation is associated with higher mortality. Identification of causes of death and contemporary risk factors for all‐cause mortality may guide interventions. Methods and Results: In the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF) study, patients with nonvalvular atrial fibrillation were randomized to rivaroxaban or dose‐adjusted warfarin. Cox proportional hazards regression with backward elimination identified factors at randomization that were independently associated with all‐cause mortality in the 14 171 participants in the intention‐to‐treat population. The median age was 73 years, and the mean CHADS2 score was 3.5. Over 1.9 years of median follow‐up, 1214 (8.6%) patients died. Kaplan–Meier mortality rates were 4.2% at 1 year and 8.9% at 2 years. The majority of classified deaths (1081) were cardiovascular (72%), whereas only 6% were nonhemorrhagic stroke or systemic embolism. No significant difference in all‐cause mortality was observed between the rivaroxaban and warfarin arms ( P =0.15). Heart failure (hazard ratio 1.51, 95% CI 1.33–1.70, P <0.0001) and age ≥75 years (hazard ratio 1.69, 95% CI 1.51–1.90, P <0.0001) were associated with higher all‐cause mortality. Multiple additional characteristics were independently associated with higher mortality, with decreasing creatinine clearance, chronic obstructive pulmonary disease, male sex, peripheral vascular disease, and diabetes being among the most strongly associated (model C‐index 0.677). Conclusions: In a large population of patients anticoagulated for nonvalvular atrial fibrillation, ≈7 in 10 deaths were cardiovascular, whereas <1 in 10 deaths were caused by nonhemorrhagic stroke or systemic embolism. Optimal prevention and treatment of heart failure, renal impairment, chronic obstructive pulmonary disease, and diabetes may improve survival. Clinical Trial Registration: URL:https://www.clinicaltrials.gov/ . Unique identifier: NCT00403767.