Long‐Term Prognosis of Brugada‐Type ECG and ECG With Atypical ST‐Segment Elevation in the Right Precordial Leads Over 20 Years: Results From the Circulatory Risk in Communities Study (CIRCS). Issue 8 (August 2016)

• Record Type: Journal Article
• Authors: Tsuneoka, Hidekazu; Takagi, Masahiko; Murakoshi, Nobuyuki; Yamagishi, Kazumasa; Yokoyama, Yasuhiro; Xu, DongZhu; Sekiguchi, Yukio; Yamasaki, Hiro; Naruse, Yoshihisa; Ito, Yoko; Igarashi, Miyako; Kitamura, Akihiko; Okada, Takeo; Tanigawa, Takeshi; Kuga, Keisuke; Ohira, Tetsuya; Tada, Hiroshi; Aonuma, Kazutaka; Iso, Hiroyasu
• Other Names: Sankai Tomoko investigator.; Umesawa Mitsumasa investigator.; Chei Choy‐Lye investigator.; Yokota Kimiko investigator.; Tabata Minako investigator.; Imano Hironori investigator.; Cui Renzhe investigator.; Ikeda Ai investigator.; Noda Hiroyuki investigator.; Ikehara Satoyo investigator.; Muraki Isao investigator.; Shimizu Yuji investigator.; Ishikawa Yoshinori investigator.; Kiyama Masahiko investigator.; Nakamura Masakazu investigator.; Maeda Kenji investigator.; Ido Masatoshi investigator.; Konishi Masamitsu investigator.; Shimamoto Takashi investigator.; Iida Minoru investigator.; Komachi Yoshio investigator.; Sato Shinichi investigator.; Naito Yoshihiko investigator.; Ozawa Hideki investigator.; Saito Isao investigator.; Sakurai Susumu investigator.; Hitsumoto Shinichi investigator.; Yao Masayuki investigator.
• Is Part Of: Journal of the American Heart Association. Volume 5:Issue 8(2016)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2016-08
• Subjects: Brugada syndrome -- electrocardiography -- epidemiology -- prognosis -- sudden cardiac death; Heart -- Diseases -- Periodicals; Cardiovascular system -- Diseases -- Periodicals; Cerebrovascular disease -- Periodicals; Cardiology -- Periodicals; 616.1
• DOI: 10.1161/JAHA.115.002899
• Languages: English
• ISSNs: 2047-9980

Abstract

Abstract : Background: Brugada syndrome is recognized as being associated with sudden cardiac death; however, the prevalence of non–type 1 Brugada‐type ECG (BrS) or atypical ST‐segment elevation in the right precordial leads (STERP) and the long‐term prognosis for those patients remain unknown. Methods and Results: We analyzed standard 12‐lead ECGs of 7178 apparently healthy participants (age range 40–64 years) who underwent health checkups from 1982 to 1986 in the Circulatory Risk in Communities Study, a prospective, large, community‐based cohort study in Japan. ECGs with J point amplitude ≥0.2 mV in the right precordial leads were divided into 3 groups: (1) type 1 BrS, (2) type 2 or 3 BrS (non‐type 1 BrS), and (3) STERP. The others served as the non–ST‐segment elevation group. We identified 8 participants (0.1%) with type1 BrS, 84 (1.2%) with non–type 1 BrS, and 228 (3.2%) with STERP. During a median follow‐up of 18.7 years (133 987.0 person‐years), sudden cardiac death was observed in no participants (0.0%) with type 1 BrS, in 1 (1.2%) with non–type 1 BrS, in 7 (3.1%) with STERP, and in 50 (0.7%) with non–ST‐segment elevation. Participants with STERP had a markedly elevated risk of sudden cardiac death (multivariable hazard ratio 3.9, 95% CI 1.7–9.0). Conclusions: STERP was associated with an elevated risk of sudden cardiac death in a middle‐aged population.