Blue light mediated C–H arylation of heteroarenes using TiO2 as an immobilized photocatalyst in a continuous-flow microreactor. Issue 8 (30th March 2017)

• Record Type: Journal Article
• Authors: Fabry, David C.; Ho, Yee Ann; Zapf, Ralf; Tremel, Wolfgang; Panthöfer, Martin; Rueping, Magnus; Rehm, Thomas H.
• Is Part Of: Green chemistry. Volume 19:Issue 8(2017)
• Page Start: 1911
• Page End: 1918
• Publication Date: 2017-03-30
• Subjects: Environmental chemistry -- Industrial applications -- Periodicals; Environmental management -- Periodicals; 660
• DOI: 10.1039/c7gc00497d
• Languages: English
• ISSNs: 1463-9262

Abstract

Abstract : Improved contacting of TiO2 catalyst, substrate and light results in an impressive boost in reactor performance for blue light mediated C–H arylation of heteroarenes in continuous-flow mode. Abstract : Titanium dioxide was applied as an immobilized photocatalyst in a microstructured falling film reactor for the continuous-flow C–H arylation of heteroarenes with aryldiazonium salts as the starting material. Detailed investigations of the catalyst and a successful long-term run proved its excellent usability for this process. Very good yields up to 99% were achieved with broad substrate scope and were compared with batch synthesis. The transfer to the continuous-flow mode revealed an impressive boost in reactor performance solely resulting from the improved irradiation and contact of the catalyst, substrate and light.