Interleukin-16 rs11556218 is associated with a risk of osteoporosis in Chinese postmenopausal women. (March 2017)

• Record Type: Journal Article
• Authors: Ma, Xiaoqing; Chen, Yuan; Zhang, Qinghua; Tian, He; Wang, Jianming; Liu, Sanyun; Wang, Baoliang; Wang, Qian
• Is Part Of: European journal of obstetrics, gynecology, and reproductive biology. Volume 210(2017)
• Page Start: 90
• Page End: 93
• Publication Date: 2017-03
• Subjects: IL-16 -- Osteoporosis -- Single-nucleotide polymorphism -- Susceptibility; Obstetrics -- Periodicals; Gynecology -- Periodicals; Reproductive health -- Periodicals; Gynecology -- Periodicals; Obstetrics -- Periodicals; Reproduction -- Periodicals; Obstétrique -- Périodiques; Gynécologie -- Périodiques; Reproduction -- Périodiques; Verloskunde; Gynaecologie; Voortplanting (biologie); Gynecology; Obstetrics; Reproduction; Electronic journals; Periodicals; Electronic journals; 618.05
• DOI: 10.1016/j.ejogrb.2016.10.009
• Languages: English
• ISSNs: 0301-2115

Abstract

Abstract: Background: Interleukins (ILs), a multifunctional cytokine, play a fundamental role in inflammatory diseases, as well as in the development of osteoporosis. However, there are no data about the role of IL-16 polymorphism in development of osteoporosis. Patients and methods: In this study, we investigated the association between the IL-16 rs11556218 T/G and rs4072122 C/T polymorphisms respectively, and the risk of osteoporosis among 230 patients with osteoporosis and 230 healthy controls. Serum IL-16 level and its correlation with the IL-16 rs11556218 T/G genotypes were analyzed. Results: Significant differences of genotype distribution were observed between osteoporosis cases and controls at the IL-16 rs11556218 T/G genotypes. Compared with the IL-16 rs11556218 T/G homozygote TT, the heterozygous TG genotype was associated with significantly increased risk for osteoporosis (OR = 2.29, 95% CI = (1.15–3.82), p = 0.026); the GG genotype was associated with increased risk for osteoporosis (OR = 1.84, 95% CI = 1.48–3.97, p = 0.015). TG and GG combined variants that were associated with increased risk for osteoporosis compared with the TT genotype (OR = 1.92, 95% CI = 1.43–4.86, p = 0.023). Moreover, in patients with osteoporosis, there was a correlation between the serum IL-16 and rs11556218 T/G genotype. However, the genotype and allele frequencies of IL-16 rs4072122 C/T polymorphisms in osteoporosis patients were not significantly different from controls. Conclusion: IL-16 rs11556218 T/G genotype was associated with increased risk for development of osteoporosis in Chinese postmenopausal women.