Increased fetal lung T2 signal is not due to increasing surfactant concentration: an in vitro T2 mapping analysis. (25th January 2017)

• Record Type: Journal Article
• Authors: Dubinsky, Theodore J.; Moshiri, Mariam; Waldorf, Kristina Adams; Wilson, Greg; Maki, Jeffrey H.; Hippe, Daniel S.
• Is Part Of: Prenatal diagnosis. Volume 37:Number 3(2017)
• Page Start: 211
• Page End: 214
• Publication Date: 2017-01-25
• Subjects: Prenatal diagnosis -- Periodicals; Fetus -- Diseases -- Diagnosis -- Periodicals; Electronic journals; 618.32075
• DOI: 10.1002/pd.4987
• Languages: English
• ISSNs: 0197-3851

Abstract

Abstract: Object: The aim of this study was to perform in vitro T2 mapping of serial dilutions of pharmaceutical surfactant. Materials and methods: Magnetic resonance imaging. Magnetic resonance scanning was performed on serial dilutions of surfactant on large bore clinical magnets at a field strength of 1.5 T Philips and 3.0 T (Achieva TX, Philips Healthcare, the Netherlands). Results: The curves demonstrate a small increasing trend between surfactant concentration and R2 (shortened T2's), with a 7.3% increase in R2 for each doubling of surfactant concentration (95% confidence interval: 6.1–8.6%, p < 0.001). Conclusions: The increasing lung/liver T2 signal ratio seen in fetal lungs with increasing gestational age is not due to increasing surfactant concentration. © 2016 John Wiley & Sons, Ltd. Abstract : What's already known about this topic? T2 signal increases in fetal lungs with gestational age. What does this study add? Mechanism of why this occurs