Utilizing on‐ and off‐line monitoring tools to follow a kinetic resolution step during flow synthesis. (11th August 2016)

• Record Type: Journal Article
• Authors: Farley, Kathleen A.; Reilly, Usa; Anderson, Dennis P.; Boscoe, Brian P.; Bundesmann, Mark W.; Foley, David A.; Lall, Manjinder S.; Li, Chao; Reese, Matthew R.; Yan, Jiangli
• Other Names: Williamson R. Thomas guestEditor.; Marquez Bryan L. guestEditor.
• Is Part Of: Magnetic resonance in chemistry. Volume 55:Number 4(2017:Apr.)
• Page Start: 348
• Page End: 354
• Publication Date: 2016-08-11
• Subjects: flow NMR -- flow IR -- reaction monitoring -- 1H NMR -- flow synthesis -- enzyme -- kinetic resolution; Nuclear magnetic resonance spectroscopy -- Periodicals; Chemistry, Organic -- Periodicals; Magnetic resonance -- Periodicals; 538.36
• DOI: 10.1002/mrc.4494
• Languages: English
• ISSNs: 0749-1581

Abstract

Abstract: In situ reaction monitoring tools offer the ability to track the progress of a synthetic reaction in real time to facilitate reaction optimization and provide kinetic/mechanistic insight. Herein, we report the utilization of flow NMR, flow IR, and other off‐line spectroscopy tools to monitor the progress of a flow chemistry reaction. The on‐line and off‐line tools were selected to facilitate the stereoselective kinetic resolution of a key racemic monomer, which lacked a chromophore, making conventional reaction monitoring difficult. Copyright © 2016 John Wiley & Sons, Ltd. Abstract : In situ reaction monitoring tools offer the ability to track the progress of a synthetic reaction in real time to facilitate reaction optimization and provide kinetic/mechanistic insight. Herein, we report the utilization of flow NMR, flow IR, and other off‐line spectroscopy tools to monitor the progress of a flow chemistry reaction. The on‐line and off‐line tools were selected to facilitate the stereoselective kinetic resolution of a key racemic monomer, which lacked a chromophore, making conventional reaction monitoring difficult.