Copper-catalyzed regioselective synthesis of furan via tandem cycloaddition of ketone with an unsaturated carboxylic acid under air. Issue 1 (5th November 2014)

• Record Type: Journal Article
• Authors: Ghosh, Monoranjan; Mishra, Subhajit; Monir, Kamarul; Hajra, Alakananda
• Is Part Of: Organic & biomolecular chemistry. Volume 13:Issue 1(2015)
• Page Start: 309
• Page End: 314
• Publication Date: 2014-11-05
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c4ob01320d
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A catalytic decarboxylative annulation has been developed for the regioselective synthesis of furans by the cycloaddition of ketones with α, β-unsaturated carboxylic acids in ambient air. Abstract : A catalytic decarboxylative annulation has been developed for the regioselective synthesis of trisubstituted furans by the cycloaddition of ketones with α, β-unsaturated carboxylic acids under ambient air. A library of furan derivatives were obtained in good yields from the readily available substrates in the combination of a catalytic amount of Cu-salt and a stoichiometric amount of water. Water plays a crucial role in this catalytic transformation.