Cationic azacryptands as selective three-way DNA junction binding agents. Issue 1 (4th November 2014)

• Record Type: Journal Article
• Authors: Novotna, Jana; Laguerre, Aurelien; Granzhan, Anton; Pirrotta, Marc; Teulade-Fichou, Marie-Paule; Monchaud, David
• Is Part Of: Organic & biomolecular chemistry. Volume 13:Issue 1(2015)
• Page Start: 215
• Page End: 222
• Publication Date: 2014-11-04
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c4ob01846j
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Azacryptands are promising candidates for assessing the therapeutic potential of three-way DNA junctions. Abstract : DNA damaging agents are among the most powerful anticancer drugs currently in clinical use. As an alternative to irreversible nucleobase damage and DNA strand breaks, the non-covalent stabilization of unusual, non-B DNA structures is currently emerging as a promising way to cause DNA damage with a high level of specificity. One of such non-B DNA structures is the three-way DNA junction: this Y-shaped multi-stranded architecture may act as an impediment to many DNA transactions, being therefore regarded as an invaluable target to create genomic defects that are improperly dealt with by cancer cells only. Herein, we report on a series of cationic azacryptands that make excellent candidates for assessing and harnessing the actual therapeutic potential of three-way DNA junction interacting compounds.