Development of fluorescent probes based on protection–deprotection of the key functional groups for biological imaging. (14th May 2015)

• Record Type: Journal Article
• Authors: Tang, Yonghe; Lee, Dayoung; Wang, Jiaoliang; Li, Guanhan; Yu, Jinghua; Lin, Weiying; Yoon, Juyoung
• Is Part Of: Chemical Society reviews. Volume 44:Number 15(2015:Aug.)
• Page Start: 5003
• Page End: 5015
• Publication Date: 2015-05-14
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c5cs00103j
• Languages: English
• ISSNs: 0306-0012

Abstract

Abstract : This review highlights the recent protection–deprotection methods of aldehyde, hydroxyl, or amino groups for the development of fluorescent imaging probes. Abstract : Recently, the strategy of protection–deprotection of functional groups has been widely employed to design fluorescent probes, as the protection–deprotection of functional groups often induces a marked change in electronic properties. Significant advances have been made in the development of analyte-responsive fluorescent probes based on the protection–deprotection strategy. In this tutorial review, we highlight the representative examples of small-molecule based fluorescent probes for bioimaging, which are operated via the protection–deprotection of key functional groups such as aldehyde, hydroxyl, and amino functional groups reported from 2010 to 2014. The discussion includes the general protection–deprotection methods for aldehyde, hydroxyl, or amino groups, as well as the design strategies, sensing mechanisms, and deprotection modes of the representative fluorescent imaging probes applied to bio-imaging.