Auditory seizures in autoimmune epilepsy: a case with anti‐thyroid antibodies. Issue 1 (March 2017)

• Record Type: Journal Article
• Authors: Varrasi, Claudia; Vecchio, Domizia; Magistrelli, Luca; Strigaro, Gionata; Tassi, Laura; Cantello, Roberto
• Is Part Of: Epileptic disorders. Volume 19:Issue 1(2017)
• Page Start: 99
• Page End: 103
• Publication Date: 2017-03
• Subjects: Hashimoto's encephalopathy -- autoimmune encephalopathy -- status epilepticus -- anti‐thyroid antibodies; Epilepsy -- Periodicals; 616.853
• DOI: 10.1684/epd.2017.0904
• Languages: English
• ISSNs: 1294-9361

Abstract

Abstract: In its classic presentation, Hashimoto's encephalopathy is an acute‐subacute complex neuropsychiatric syndrome with cognitive impairment, hallucinations, myoclonus, tremor or ataxia, associated with elevated anti‐thyroid antibodies. Corticoids and immunotherapy are dramatically effective. However, in some cases, not all the associated features are presented and this delays diagnosis and appropriate treatment. We describe a man with abrupt onset of recurrent auditory seizures resulting in refractory non‐convulsive status epilepticus. The patient was diagnosed with an autoimmune encephalopathy with elevated serum and CSF anti‐thyroid antibodies. None of the antiepileptic drugs were successful, however, following immune‐modulating therapy, the refractory non‐convulsive status epilepticus dramatically improved, as did the patient overall. We suggest that Hashimoto's encephalopathy should be suspected in otherwise healthy patients with unexplained new‐onset focal recurrent auditory seizures which do not respond to antiepileptic drugs. The presence of anti‐thyroid antibodies in the CSF supports this diagnosis.