The blood–brain barrier and protein‐mediated fatty acid uptake: role of the blood–brain barrier as a metabolic barrier: An Editorial Comment for 'The blood‐brain barrier fatty acid transport protein 1 (FATP1/SLC27A1) supplies docosahexaenoic acid to the brain, and insulin facilitates transport'. Issue 3 (30th March 2017)

• Record Type: Journal Article
• Authors: Murphy, Eric J.
• Is Part Of: Journal of neurochemistry. Volume 141:Issue 3(2017)
• Page Start: 324
• Page End: 329
• Publication Date: 2017-03-30
• Subjects: Neurochemistry -- Periodicals; 616.8042
• DOI: 10.1111/jnc.14000
• Languages: English
• ISSNs: 0022-3042

Abstract

Abstract : Read the commented article 'The blood-brain barrier fatty acid transport protein 1 (FATP1/SLC27A1) supplies docosahexaenoic acid to the brain, and insulin facilitates transport' on page 400 . Abstract : This Editorial comment on a study by Yusuke and coworkers, in the current issue of the Journal of Neurochemistry, that adds to increasing evidence for a role of proteins in facilitating fatty acid uptake into the brain. Fatty acid transport proteins (FATP), fatty acid translocase (CD36), and fatty acid binding proteins (FABP) are all localized in brain microvascular endothelial cells that constitute the blood–brain barrier (BBB). The authors show that FATP1 accounts for about 60% of docosahexaenoic acid (DHA) uptake. The role of the BBB functioning as a selective metabolic barrier for fatty acids is unappreciated but promoted herein. Read the commented article 'The blood-brain barrier fatty acid transport protein 1 (FATP1/SLC27A1) supplies docosahexaenoic acid to the brain, and insulin facilitates transport' on page 400 .