A new class of ribozyme from hepatitis B virus. (April 2017)

• Record Type: Journal Article
• Authors: Lim, Chun Shen; Brown, Christopher
• Is Part Of: FEBS journal. Volume 284:Number 8(2017)
• Page Start: 1182
• Page End: 1183
• Publication Date: 2017-04
• Subjects: Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pathology, Molecular -- Periodicals; 572
• DOI: 10.1111/febs.14062
• Languages: English
• ISSNs: 1742-464X

Abstract

Abstract : In this issue, Chakraborty and Ghosh present initial in vitro data indicating a 53‐base part of the hepatitis B virus (HBV) epsilon region is a ribozyme with unusual properties. Self‐cleavage first occurred at the HBV non‐canonical polyadenylation signal UAUAAA and the "centre bulge" of the epsilon region, releasing a ribozyme. The released ribozyme then acted as a new class of trans‐cleaving ribozyme cleaving other RNAs.