Comparison of clinicopathological characteristics between T‐cell prolymphocytic leukemia and peripheral T‐cell lymphoma, not otherwise specified. (3rd March 2017)

• Record Type: Journal Article
• Authors: Kawamoto, Keisuke; Miyoshi, Hiroaki; Yanagida, Eriko; Yoshida, Noriaki; Kiyasu, Junichi; Kozai, Yasuji; Morikita, Tatsuma; Kato, Takeharu; Suzushima, Hitoshi; Tamura, Shinobu; Muta, Tsuyoshi; Kato, Koji; Eto, Tetsuya; Seki, Ritsuko; Nagafuji, Koji; Sone, Hirohito; Takizawa, Jun; Seto, Masao; Ohshima, Koichi
• Is Part Of: European journal of haematology. Volume 98:Number 5(2017:May)
• Page Start: 459
• Page End: 466
• Publication Date: 2017-03-03
• Subjects: overall survival -- peripheral T‐cell lymphoma, not otherwise specified -- T‐cell prolymphocytic leukemia; Hematology -- Periodicals; Blood -- Diseases -- Periodicals; Blood -- Periodicals; 616.15005
• DOI: 10.1111/ejh.12856
• Languages: English
• ISSNs: 0902-4441

Abstract

Abstract: Objectives: T‐cell prolymphocytic leukemia (T‐PLL) is a very rare, aggressive T‐cell neoplasm. Peripheral T‐cell lymphoma, not otherwise specified (PTCL‐NOS) is also a highly aggressive lymphoma. These two diseases can often be confused with each other; therefore, we aimed to determine the clinical and pathological differences between T‐PLL and PTCL‐NOS. Methods: We analyzed 15 T‐PLL and 91 PTCL‐NOS patients and also compared clinical features between T‐PLL and PTCL‐NOS with leukemic presentation. Peripheral blood images and biopsy specimens were analyzed, and treatment responses were determined via imaging modalities. The clinicopathological characteristics were statistically compared. Results: T‐PLL cells were smaller in size than those of PTCL‐NOS with leukemic presentation ( P =.0068); moreover, PTCL‐NOS cells with leukemic presentation were smaller than those of PTCL‐NOS without leukemic presentation ( P =.0017). Immunophenotypic patterns in T‐PLL and PTCL‐NOS were similar. Five‐year overall survival rates of T‐PLL and all PTCL‐NOS patients were 57.5% and 36.8%, respectively. No significant differences were found in clinical manifestations or prognoses; T‐PLL and PTCL‐NOS with leukemic presentation had essentially equivalent characteristics. Conclusion: T‐PLL and PTCL‐NOS may share common biological and clinical characteristics in Japanese patients.