A library of 1, 2, 3-triazole-substituted oleanolic acid derivatives as anticancer agents: design, synthesis, and biological evaluation. Issue 5 (5th December 2014)

• Record Type: Journal Article
• Authors: Wei, Gaofei; Luan, Weijing; Wang, Shuai; Cui, Shanshan; Li, Fengran; Liu, Yongxiang; Liu, Yang; Cheng, Maosheng
• Is Part Of: Organic & biomolecular chemistry. Volume 13:Issue 5(2015)
• Page Start: 1507
• Page End: 1514
• Publication Date: 2014-12-05
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c4ob01605j
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A series of novel oleanolic acid coupled 1, 2, 3-triazole derivatives have been designed and synthesized by employing a Cu(i ) catalyzed Huisgen 1, 3-dipolar cycloaddition reaction. Abstract : A series of novel oleanolic acid coupled 1, 2, 3-triazole derivatives have been designed and synthesized by employing a Cu(i ) catalyzed Huisgen 1, 3-dipolar cycloaddition reaction. The anti-proliferative evaluation indicated that some compounds exhibited excellent anti-cancer activity against the examined cancer cell lines. Among all derivatives, compound3t possesses the best inhibitory activity against HT1080 cells. A series of pharmacology experiments show that compound3t significantly induced HT1080 cell apoptosis. Therefore, this compound can serve as a promising lead candidate for further study.