Modulation of antiphospholipid antibodies‐induced trophoblast damage by different drugs used to prevent pregnancy morbidity associated with antiphospholipid syndrome. (29th January 2017)

• Record Type: Journal Article
• Authors: Alvarez, Angela M.; Balcázar, Norman; San Martín, Sebastián; Markert, Udo R.; Cadavid, Angela P.
• Is Part Of: American journal of reproductive immunology. Volume 77:Number 4(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-01-29
• Subjects: 15‐epi‐lipoxin A4 -- placental development -- pregnancy morbidity -- STAT3; Human reproduction -- Immunological aspects -- Periodicals; 616.69206
• DOI: 10.1111/aji.12634
• Languages: English
• ISSNs: 1046-7408

Abstract

Abstract : Problem: Women with antiphospholipid antibodies (aPLs) present a risk of pregnancy morbidity (PM), vascular thrombosis (VT), or both (PM/VT). aPLs affect trophoblast function, and the aim of this study was to determine the modulation of this aPL‐induced damage by different drugs. Method of study: IgG was obtained from women with PM and PM/VT positive to aPLs. Binding of IgG to trophoblastic cells, proliferation, mitochondrial membrane integrity, and trophoblast invasion were assessed. The effect of enoxaparin, aspirin, and aspirin‐triggered lipoxin (ATL) were evaluated as well as signal transducer and activator of transcription 3 (STAT3) phosphorylation. Results: IgG from women with aPLs strongly binds to trophoblastic cells. Integrity of mitochondrial membrane was reduced, and proliferation was increased by IgG‐PM/VT. Both IgG‐PM and IgG‐PM/VT decreased trophoblast invasion, which was restored by enoxaparin, aspirin, and ATL. IgG‐PM triggered reduction in STAT3 phosphorylation. Conclusion: Some drugs used to prevent aPL‐induced PM modulated the alteration of trophoblast function.