Bismuth Nitrate Catalyzed One‐Pot Multicomponent Synthesis of a Novel Series of Diversely Substituted 1, 8‐Dioxodecahydroacridines at Room Temperature#. Issue 11 (19th April 2017)

• Record Type: Journal Article
• Authors: Brahmachari, Goutam; Begam, Sanchari; Nurjamal, Khondekar
• Is Part Of: ChemistrySelect. Volume 2:Issue 11(2017)
• Page Start: 3311
• Page End: 3316
• Publication Date: 2017-04-19
• Subjects: Bi(NO3)3.5H2O -- environmentally-benign method -- functionalized 1, 8-dioxodecahydroacridines -- one-pot multicomponent reaction -- room temperature; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201700265
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: A simple, straightforward, and convenient one‐pot synthesis of a new series of diversely substituted 1, 8‐dioxodecahydroacridines (5a–q and5′a–g ), particularly bearing varying amino acids as part of the building block, has been developed based on a low‐cost and environmentally benign Bi(NO3 )3 .5H2 O catalyst via pseudo‐four component reactions of 1, 3‐cyclohexanediones (1 /4 ), various primary amines (2 ) and aldehydes (3 ) in ethanol at ambient temperature (25‐30 o C). High atom‐economy, good to excellent yields, eco‐friendliness, and mild reaction conditions are some of the important features of this protocol. Abstract : Old is gold: Bi(NO3 )3 .5H2 O, a low‐cost and environmentally benign metal salt, has further been explored as an efficient catalyst for the straightforward and convenient one‐pot synthesis of a new series of diversely substituted 1, 8‐dioxodecahydroacridines (5a–q and 5′a–g), particularly bearing varying amino acids as part of the building block, in ethanol at ambient temperature. High atom‐economy, good to excellent yields, eco‐friendliness, and mild reaction conditions are some of the important features of this protocol.