Gap junctions in C. elegans: Their roles in behavior and development. Issue 5 (22nd June 2016)

• Record Type: Journal Article
• Authors: Hall, David H.
• Other Names: Pereda Alberto E. guestEditor.; Macagno Eduardo R. guestEditor.
• Is Part Of: Developmental neurobiology. Volume 77:Issue 5(2017)
• Page Start: 587
• Page End: 596
• Publication Date: 2016-06-22
• Subjects: innexin -- nematode -- heteromeric -- heterotypic; Neurobiology -- Periodicals; Neurobiology; Neurobiologie -- Périodiques; Neurobiology; Periodicals; Periodicals; 573.838
• DOI: 10.1002/dneu.22408
• Languages: English
• ISSNs: 1932-8451

Abstract

ABSTRACT: The nematode Caenorhabditis elegans utilizes gap junctions in different fashions in virtually all of its cells. This model animal has a surprisingly large number of innexin genes within its genome, and many nematode cell types can express multiple innexins at once, leading to the formation of diverse junction types and enough redundancy to limit the effect of single gene knockdowns on animal development or behavioral phenotypes. Here, we review the general properties of these junctions, their expression patterns, and their known roles in tissue development and in the animal's connectome. © 2016 Wiley Periodicals, Inc. Develop Neurobiol 77: 587–596, 2017