The absorption kinetics of ketoconazole plays a major role in explaining the reported variability in the level of interaction with midazolam: Interplay between formulation and inhibition of gut wall and liver metabolism. (14th February 2017)

• Record Type: Journal Article
• Authors: Liu, Bo; Crewe, H. Kim; Ozdemir, Mahmut; Rowland Yeo, Karen; Tucker, Geoffrey; Rostami‐Hodjegan, Amin
• Other Names: Rostami‐Hodjegan Amin guestEditor.; Tamai Ikumi guestEditor.; Pang K. Sandy guestEditor.
• Is Part Of: Biopharmaceutics & drug disposition. Volume 38:Number 3(2017:Apr.)
• Page Start: 260
• Page End: 270
• Publication Date: 2017-02-14
• Subjects: Ketoconazole -- midazolam -- DDI -- inter‐individual variability -- absorption; Biopharmaceutics -- Periodicals; Drugs -- Metabolism -- Periodicals; Pharmacology -- Periodicals; Biopharmaceutics -- Periodicals; Pharmaceutical Preparations -- metabolism -- Periodicals; 615.19
• DOI: 10.1002/bdd.2058
• Languages: English
• ISSNs: 0142-2782

Abstract

Abstract: The impact of different single oral doses of ketoconazole (KTZ) (100, 200 and 400 mg) and of staggering its dosage (400 mg at −12, −2, 0, 2 and 4 h), with respect to the administration of a single 5 mg oral dose of midazolam (MDZ) on the extent of inhibition of the metabolism of the latter, was evaluated in healthy subjects in two separate studies. Escalation of the ketoconazole dosage resulted in 2.3 (1.9), 2.7 (1.7) and 4.2 (2.5) ‐fold increases in the mean AUC (0, 12h) (and C max ) values of midazolam. Dose‐staggering was associated with 3.9 (2.5), 4.9 (2.9), 5.4 (2.8), 2.0 (1.3) and 1.2 (0.9) ‐fold increases in the mean AUC (0, 12h) (and C max ) of midazolam. These findings could be predicted by physiologically based pharmacokinetic (PBPK) modelling using the ADAM (advanced dissolution absorption and metabolism) model within the Simcyp Simulator (Version 12 Release 2) to characterize the absorption kinetics of ketoconazole with respect to disintegration time, supersaturation ratio and precipitation rate. This study also emphasizes a need to account for inter‐individual variability in the gut wall and systemic exposure of inhibitors with physicochemical properties similar to ketoconazole, in particular in their rate of oral absorption and when using different pharmaceutical formulations, in designing and evaluating the extent of drug–drug interactions. Copyright © 2016 John Wiley & Sons, Ltd.