What does the susceptible-dose dependent interpretive category for cefepime in ESBL-producing bacteria?. (4th May 2017)

• Record Type: Journal Article
• Authors: Menegucci, Thatiany Cevallos; Bastos, Marina de Souza; Viana, Giselle Fukita; Moreira, Rafael Renato Brondani; Garcia, Lourdes Botelho; Cardoso, Celso Luiz; Tognim, Maria Cristina Bronharo
• Is Part Of: Journal of chemotherapy. Volume 29:Number 3(2017)
• Page Start: 189
• Page End: 194
• Publication Date: 2017-05-04
• Subjects: Cefepime -- Minimum inhibitory concentration -- Susceptible-dose dependent -- Extended-spectrum β-lactamase -- Klebsiella pneumoniae -- Enterobacter cloacae; Chemotherapy -- Periodicals; Drug Therapy -- Periodicals; 615.58
• DOI: 10.1080/1120009X.2015.1120407
• Languages: English
• ISSNs: 1120-009X

Abstract

Abstract : In this study, we investigated the frequency of isolates included in the susceptible-dose dependent (SDD) category, according to the Clinical and Laboratory Standards Institute guidelines, carrying bla TEM, bla SHV and bla CTX genes among 92 Klebsiella pneumoniae and 80 Enterobacter cloacae clinical isolates. The presence of one or more extended-spectrum β-lactamases (ESBLs) genes was observed in 64% K. pneumoniae and 69% E. cloacae isolates. Nineteen isolates were included in SDD interpretive category criteria, of which 15 carried ESBL genes (seven K. pneumoniae and eight E. cloacae ). Considering the high proportion of ESBL gene-containing isolates included in the SDD category (79%), we recommend that physicians exercise caution in the use of cefepime for treatment of infections caused by these isolates, reducing possible therapeutic failure, particularly in cases of ESBL-producing bacterial strains.