The role of Lawesson's reagent in the total synthesis of macrocyclic natural products. (4th May 2017)

• Record Type: Journal Article
• Authors: Larik, Fayaz Ali; Saeed, Aamer; Muqadar, Urooj; El-Seedi, Hesham; Faisal, Muhammad; Channar, Pervaiz Ali; Mehfooz, Haroon
• Is Part Of: Phosphorus, sulfur, and silicon and the related elements. Volume 192:Number 5(2017)
• Page Start: 490
• Page End: 502
• Publication Date: 2017-05-04
• Subjects: Lawesson's reagent -- macrocycles -- total synthesis -- thionation -- medicinal value; Sulfur compounds -- Periodicals; Organosulfur compounds -- Periodicals; Phosphorus compounds -- Periodicals; Organophosphorus compounds -- Periodicals; Silicon compounds -- Periodicals; Organosilicon compounds -- Periodicals; 546
• DOI: 10.1080/10426507.2016.1259236
• Languages: English
• ISSNs: 1042-6507

Abstract

GRAPHICAL ABSTRACT: ABSTRACT: This review, including 111 references, describes the applications of Lawesson's reagent (LR) [2, 4-bis( p -methoxyphenyl)-1, 3, 2, 4-dithiadiphosphetane-2, 4-dithione] for the total synthesis of macrocyclic natural products. LR is a versatile reagent and shows excellent regioselectivity, chemoselectivity, and offers the products in high yield. The thionation of carbonyl moieties present in macrocyclic natural products, and cyclization to construct key heterocyclic fragments is described. Moreover, this review highlights the medicinal significance of the natural products.