Broad scope gold(i)-catalysed polyenyne cyclisations for the formation of up to four carbon–carbon bonds. Issue 10 (27th February 2017)

• Record Type: Journal Article
• Authors: Rong, Zhouting; Echavarren, Antonio M.
• Is Part Of: Organic & biomolecular chemistry. Volume 15:Issue 10(2017)
• Page Start: 2163
• Page End: 2167
• Publication Date: 2017-02-27
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c7ob00235a
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : The polycyclisation of polyeneynes catalyzed by gold(i ) has been extended for the first time to the simultaneous formation of up to four carbon–carbon bonds, leading to steroid-like molecules with high stereoselectivity in a single step with low catalyst loadings. Abstract : The polycyclisation of polyenynes catalyzed by gold(i ) has been extended for the first time to the simultaneous formation of up to four carbon–carbon bonds, leading to steroid-like molecules with high stereoselectivity in a single step with low catalyst loadings. In addition to terminal alkynes, bromoalkynes can also be used as initiators of polyene cyclisations, giving rise to synthetically useful cyclic bromoalkenes.