A 4, 5-quinolimide-based fluorescent sensor for the turn-on detection of Cd2+ with live-cell imaging. Issue 10 (21st February 2017)

• Record Type: Journal Article
• Authors: Zhang, Yu; Guo, Xiangfeng; Zheng, Mengmeng; Yang, Rui; Yang, Hongming; Jia, Lihua; Yang, Mengmeng
• Is Part Of: Organic & biomolecular chemistry. Volume 15:Issue 10(2017)
• Page Start: 2211
• Page End: 2216
• Publication Date: 2017-02-21
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c7ob00201g
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : The first 4, 5-quinolimide sensor, BNA, bearing the amide-DPA receptor, was reported for sensing Cd 2+ with live-cell imaging. Abstract : A 4, 5-quinolimide derivative, BNA, bearing the amide-DPA receptor, was synthesized as a turn-on fluorescent sensor for Cd 2+ . Under physiological conditions, BNA could distinguish Cd 2+ from Zn 2+, showing turn-on fluorescence behaviour and an increased fluorescence lifetime.BNA and Cd 2+ formed a 1 : 1 stoichiometric complex, and the detection limit was measured to be as low as 11 nM. Furthermore, BNA was utilized for fluorescence imaging of Cd 2+ in live cells. To the best of our knowledge, it is the first 4, 5-quinolimide-based sensor for the detection of metal ions.