A highly enantioselective Friedel–Crafts reaction of 3, 5-dimethoxylphenol with nitroolefins mediated by a bifunctional quinine derived thiourea catalyst. Issue 16 (6th April 2017)

• Record Type: Journal Article
• Authors: Han, Xiaoyu; Ye, Can; Chen, Fenfen; Chen, Qu; Wang, Yongjiang; Zeng, Xiaofei
• Is Part Of: Organic & biomolecular chemistry. Volume 15:Issue 16(2017)
• Page Start: 3401
• Page End: 3407
• Publication Date: 2017-04-06
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c7ob00372b
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A useful and highly enantioselective Friedel–Crafts reaction of 3, 5-dimethoxylphenol with nitroolefins catalyzed by a bifunctional quinine derived thiourea catalyst was developed. Abstract : A useful enantioselective Friedel–Crafts reaction of 3, 5-dimethoxylphenol with nitroolefins catalyzed by a bifunctional quinine derived thiourea catalyst9 was developed. The Michael addition products could be obtained in good to high yields (68–92%) and with excellent enantioselectivities (89–98% ee). Such a reaction is exceptionally attractive in virtue of its simple protocol, ready availability of the starting materials, and practical applications of the products.