Pd/Cu-catalyzed dual C–H bond carbonylation towards the synthesis of fluorazones. Issue 31 (3rd April 2017)

• Record Type: Journal Article
• Authors: Liao, Fan; Shi, Renyi; Sha, Yuchen; Xia, Jianhui; Liao, Weilin; Lei, Aiwen
• Is Part Of: Chemical communications. Volume 53:Issue 31(2017)
• Page Start: 4354
• Page End: 4357
• Publication Date: 2017-04-03
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c7cc01707c
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Pd catalyzed oxidative dual C–H bond activation/carbonylation still remains a great challenge due to the generation of by-products via C–C bond formation. Herein, we developed a straightforward Pd/Cu-catalyzed oxidative dual C–H bond carbonylation process to access biologically and pharmaceutically important fluorazones from easily available N -aryl pyrroles and CO utilizing O2 as the terminal oxidant. Abstract : Pd/Cu catalyzed oxidative dual C–H bond activation/carbonylation still remains a great challenge due to the generation of by-products via C–C bond formation. Herein we developed a straightforward Pd/Cu-catalyzed oxidative dual C–H bond carbonylation process to access biologically and pharmaceutically important fluorazones from easily available N -aryl pyrroles and CO. A wide range of functional groups were well tolerated in this transformation, and O2 could be utilized as the only terminal oxidant to promote the oxidative carbonylation process.