Copper-catalyzed C–O bond cleavage and cyclization: synthesis of indazolo[3, 2-b]quinazolinones. Issue 10 (10th January 2017)

• Record Type: Journal Article
• Authors: Qiao, Rui; Ye, Leping; Hu, Kun; Yu, Shuling; Yang, Weiguang; Liu, Miaochang; Chen, Jiuxi; Ding, Jinchang; Wu, Huayue
• Is Part Of: Organic & biomolecular chemistry. Volume 15:Issue 10(2017)
• Page Start: 2168
• Page End: 2173
• Publication Date: 2017-01-10
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c6ob02352e
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Cu-catalyzed sequential inert C–O bond cleavage followed by intramolecular C–N bond formation for the synthesis of indazolo[3, 2- b ]quinazolinones. Abstract : The first example of a copper-catalyzed halogen-free protocol to construct indazolo[3, 2- b ]quinazolinones was developed through sequential inert C–O bond cleavage followed by intramolecular C–N bond formation. This protocol represents an efficient synthetic tool for accessing a more diverse range of functionalized indazolo[3, 2- b ]quinazolinones. The structure of the newly synthesized indazolo[3, 2- b ]quinazolinones was unambiguously confirmed by X-ray crystal diffraction analysis.