Annexin A1 influences in breast cancer: Controversies on contributions to tumour, host and immunoediting processes. (May 2017)

• Record Type: Journal Article
• Authors: Tu, Yan; Johnstone, Cameron N.; Stewart, Alastair G.
• Is Part Of: Pharmacological research. Volume 119(2017:May)
• Page Start: 278
• Page End: 288
• Publication Date: 2017-05
• Subjects: ALH atypical lobular hyperplasia -- BC breast cancer -- BEC blood endothelial cell -- BL basal-like -- CAF cancer-associated fibroblast -- DC dendritic cells -- DCIS ductal carcinoma in situ -- EAE experimental autoimmune encephalomyelitis -- EMT epithelial-mesenchymal transition -- ER estrogen receptor -- FPR formyl peptide receptor -- GPCR G-protein coupled receptor -- HER2 human epidermal growth factor receptor 2 -- IDC invasive ductal carcinoma -- IFN-γ interferon gamma -- ILC invasive lobular carcinoma -- LCIS lobular carcinoma in situ -- LEC lymphatic endothelial cell -- MDSC myeloid-derived suppressor cell -- NK natural killer cell -- PR progesterone receptor -- PT primary tumour -- TGF-β transforming growth factor beta -- TNBC triple negative breast cancer -- TNFα tumour necrosis factor alpha; Annexin A1 -- Cancer immunoediting -- Breast cancer -- Tumour microenvironment -- Tumour stroma; Pharmacology -- Periodicals; Pharmacology -- Periodicals; Research -- Periodicals; Médicaments -- Recherche -- Périodiques; Pharmacologie -- Périodiques; 615.105
• DOI: 10.1016/j.phrs.2017.02.011
• Languages: English
• ISSNs: 1043-6618

Abstract

Graphical abstract: Abstract: Annexin A1 is a multifunctional protein characterised by its actions in modulating the innate and adaptive immune response. Accumulating evidence of altered annexin A1 expression in many human tumours raises interest in its functional role in cancer biology. In breast cancer, altered annexin A1 expression levels suggest a potential influence on tumorigenic and metastatic processes. However, reports of conflicting results reveal a relationship that is much more complex than first conceptualised. In this review, we explore the diverse actions of annexin A1 on breast tumour cells and various host cell types, including stromal immune and structural cells, particularly in the context of cancer immunoediting.