Sex-gender-related therapeutic approaches for cardiovascular complications associated with diabetes. (May 2017)

• Record Type: Journal Article
• Authors: Campesi, Ilaria; Franconi, Flavia; Seghieri, Giuseppe; Meloni, Marco
• Is Part Of: Pharmacological research. Volume 119(2017:May)
• Page Start: 195
• Page End: 207
• Publication Date: 2017-05
• Subjects: ARBs angiotensin II type 1 receptor blockers -- BH4 tetrahydrobiopterin -- BMI body mass index -- CABG coronary artery bypass graft -- EPCs endothelial progenitor cells -- ERα estrogen receptor alpha -- ERβ estrogen receptor beta -- GLUT4 glucose transporter 4 -- HbA1c glycated haemoglobin -- HDL lower high-density lipoprotein -- HRT hormone replacement therapy -- IFG impaired fasting glucose -- IGT impaired glucose tolerance -- iPS induced pluripotent stem cells -- MI myocardial infarction -- MRFIT Multiple Risk Factor Intervention Trial -- PAD peripheral arterial disease -- PCI percutaneous coronary intervention -- STEMI ST-elevation MI -- TZDs thiazolidinediones; Diabetes mellitus -- Sex-gender differences -- Risk factors -- Cardiovascular complications -- Therapeutic approaches; Pharmacology -- Periodicals; Pharmacology -- Periodicals; Research -- Periodicals; Médicaments -- Recherche -- Périodiques; Pharmacologie -- Périodiques; 615.105
• DOI: 10.1016/j.phrs.2017.01.023
• Languages: English
• ISSNs: 1043-6618

Abstract

Graphical abstract: Abstract: Diabetes is a chronic disease associated with micro- and macrovascular complications and is a well-established risk factor for cardiovascular disease. Cardiovascular complications associated with diabetes are among the most important causes of death in diabetic patients. Interestingly, several sex-gender differences have been reported to significantly impact in the pathophysiology of diabetes. In particular, sex-gender differences have been reported to affect diabetes epidemiology, risk factors, as well as cardiovascular complications associated with diabetes. This suggests that different therapeutic approaches are needed for managing diabetes-associated cardiovascular complications in men and women. In this review, we will discuss about the sex-gender differences that are known to impact on diabetes, mainly focusing on the cardiovascular complications associated with the disease. We will then discuss the therapeutic approaches for managing diabetes-associated cardiovascular complications and how differences in sex-gender can influence the existing therapeutic approaches.