Gut microbiota: Implications in Parkinson's disease. (May 2017)

• Record Type: Journal Article
• Authors: Parashar, Arun; Udayabanu, Malairaman
• Is Part Of: Parkinsonism & related disorders. Volume 38(2017)
• Page Start: 1
• Page End: 7
• Publication Date: 2017-05
• Subjects: Gut microbiota -- Parkinson's disease -- Probiotics -- Germ-free -- Antibiotics -- Fecal transplant; Parkinson's disease -- Periodicals; Movement disorders -- Periodicals; Movement Disorders -- Periodicals; Nerve Degeneration -- Periodicals; Nervous System Diseases -- Periodicals; Parkinson Disease -- Periodicals; Tremor -- Periodicals; Parkinson, Maladie de -- Périodiques; Parkinson's disease; 616.833
• DOI: 10.1016/j.parkreldis.2017.02.002
• Languages: English
• ISSNs: 1353-8020

Abstract

Abstract: Gut microbiota (GM) can influence various neurological outcomes, like cognition, learning, and memory. Commensal GM modulates brain development and behavior and has been implicated in several neurological disorders like Alzheimer's disease, multiple sclerosis, amyotrophic lateral sclerosis, anxiety, stress and much more. A recent study has shown that Parkinson's disease patients suffer from GM dysbiosis, but whether it is a cause or an effect is yet to be understood. In this review, we try to connect the dots between GM and PD pathology using direct and indirect evidence. Highlights: Possible connections between gut microbiota and Parkinson's pathology. Mediatory role of gut microbiota in neurological disorders. Gut microbiota, insights into mechanistic control over brain and behavior.