Genomic analysis of a Streptococcus pyogenes strain causing endocarditis in a child. (May 2017)

• Record Type: Journal Article
• Authors: Beye, M.; El Karkouri, K.; Labas, N.; Raoult, D.; Fournier, P.-E.
• Is Part Of: New microbes and new infections. Volume 17(2017)
• Page Start: 1
• Page End: 6
• Publication Date: 2017-05
• Subjects: Endocarditis -- genome comparison -- real-time genome sequencing -- Streptococcus pyogenes -- virulence; Medical microbiology -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; Microbiology -- Periodicals; Communicable Diseases -- Periodicals; Infection -- Periodicals; 616.9041
• DOI: 10.1016/j.nmni.2017.01.007
• Languages: English
• ISSNs: 2052-2975

Abstract

Abstract: We sequenced the genome of Streptococcus pyogenes strain G773 that caused an infective endocarditis in a 4-year-old boy suffering from acute endocarditis. The 1.9-Mb genome exhibited a specific combination of virulence factors including a complete integrative and conjugative element, sp2905, previously described as incomplete in S . pyogenes, and five bacteriocin-coding genes. However, strain G773 lacked a CRISPR-Cas system.