Lipid - Motor Interactions: Soap Opera or Symphony?. (February 2017)

• Record Type: Journal Article
• Authors: Pathak, Divya; Mallik, Roop
• Is Part Of: Current opinion in cell biology. Volume 44(2017)
• Page Start: 79
• Page End: 85
• Publication Date: 2017-02
• Subjects: Cells -- Periodicals; Cytology -- Periodicals; Cell Biology -- Periodicals; Biology -- Periodicals; Cells -- Periodicals; Review Literature -- Periodicals; Cell Biology; Biology; Cells; Review Literature; Cellules -- Périodiques; Cytologie -- Périodiques; Electronic journals; 571.6
• DOI: 10.1016/j.ceb.2016.09.005
• Languages: English
• ISSNs: 0955-0674

Abstract

Abstract : Intracellular transport of organelles can be driven by multiple motor proteins that bind to the lipid membrane of the organelle and work as a team. We review present knowledge on how lipids orchestrate the recruitment of motors to a membrane. Looking beyond recruitment, we also discuss how heterogeneity and local mechanical properties of the membrane may influence function of motor-teams. These issues gain importance because phagocytosed pathogens use lipid-centric strategies to manipulate motors and survive in host cells.