And Akt‐ion! IQGAP1 in control of signaling pathways. (20th March 2017)

• Record Type: Journal Article
• Authors: Choi, Suyong; Anderson, Richard A
• Is Part Of: EMBO journal. Volume 36:Number 8(2017)
• Page Start: 967
• Page End: 969
• Publication Date: 2017-03-20
• Subjects: Molecular biology -- Periodicals; 572.805
• DOI: 10.15252/embj.201796827
• Languages: English
• ISSNs: 0261-4189

Abstract

Abstract : ERK signaling and Akt signaling are inversely correlated in some cancers. Yet, the precise molecular mechanism for cross‐inhibition remains unclear. In this issue of The EMBO Journal, Pan et al (2017 ) show that when Akt is on, its phosphorylated cytoplasmic substrate FOXO1 turns off ERK activity by reshaping the Ras‐ERK scaffold IQGAP1. Abstract : ERK and Akt signaling are inversely correlated in some cancers. New work shows that Akt‐phosphorylated FOXO1 turns off ERK activity by reshaping the Ras‐ERK scaffold protein IQGAP1.