Prognostic value of the seventh AJCC/UICC TNM classification of intestinal‐type ethmoid adenocarcinoma: Systematic review and risk prediction model. Issue 4 (9th January 2017)

• Record Type: Journal Article
• Authors: Fiaux–Camous, Domitille; Chevret, Sylvie; Oker, Natalie; Turri–Zanoni, Mario; Lombardi, Davide; Choussy, Olivier; Duprez, Frederic; Jorissen, Marc; de Gabory, Ludovic; Malard, Olivier; Herman, Philippe; Nicolai, Piero; Castelnuovo, Paolo; Verillaud, Benjamin
• Is Part Of: Head & neck. Volume 39:Issue 4(2017)
• Page Start: 668
• Page End: 678
• Publication Date: 2017-01-09
• Subjects: ethmoid -- adenocarcinoma -- intestinal‐type adenocarcinoma (ITAC) -- TNM classification -- endoscopic resection with transnasal craniectomy; Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.24663
• Languages: English
• ISSNs: 1043-3074

Abstract

Abstract: Background: The purpose of this study was to propose a prognostic classification of intestinal‐type adenocarcinoma (ITAC) based on literature search and prognostic modeling of cohort data. Methods: We first conducted a literature search to assess the homogeneity of the reported estimates of 5‐year survival and to identify the influence of T classification. We then pooled prospective data from 3 large French and Italian series to predict time to all‐cause mortality. The sample was randomly split to derive and then to validate the proposed prognostic model. Results: Literature analysis confirmed the heterogeneity in 5‐year survival rates, partly explained in subsets of homogeneous T‐values. The sample included 223 patients, randomly separated into a derivation ( n = 141) and a validation set ( n = 82). Invasion of the sphenoid lateral and/or posterior walls and dura/cerebral invasion were systematically associated with a poor survival. Conclusion: The incorporation of the invasion of the sphenoid lateral or posterior walls should be considered for ITAC management and prognostication. © 2017 Wiley Periodicals, Inc. Head Neck 39: 668–678, 2017