Efficient merging of copper and photoredox catalysis for the asymmetric cross-dehydrogenative-coupling of alkynes and tetrahydroisoquinolines. Issue 2 (5th November 2014)

• Record Type: Journal Article
• Authors: Perepichka, Inna; Kundu, Soumen; Hearne, Zoë; Li, Chao-Jun
• Is Part Of: Organic & biomolecular chemistry. Volume 13:Issue 2(2015)
• Page Start: 447
• Page End: 451
• Publication Date: 2014-11-05
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c4ob02138j
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A highly efficient catalytic asymmetric alkynylation of prochiral CH2 groups in tetrahydroisoquinoline was developed using copper catalyzed cross-dehydrogenative-coupling of sp 3 and sp C–H bonds with the assistance of a photocatalyst and visible light. Abstract : A highly efficient catalytic asymmetric alkynylation of prochiral CH2 groups in tetrahydroisoquinoline was developed using copper catalyzed cross-dehydrogenative-coupling of sp 3 and sp C–H bonds with the assistance of a photocatalyst and visible light.