Polyhydroxyalkanoate‐based drug delivery systems. Issue 5 (28th November 2016)

• Record Type: Journal Article
• Authors: Michalak, Michał; Kurcok, Piotr; Hakkarainen, Minna
• Is Part Of: Polymer international. Volume 66:Issue 5(2017:May)
• Page Start: 617
• Page End: 622
• Publication Date: 2016-11-28
• Subjects: polyhydroxyalkanoate -- poly(3‐hydroxybutyrate) -- drug delivery -- nanoparticle -- drug conjugate; Plastics -- Periodicals; Polymers -- Periodicals; Polymerization -- Periodicals; 547.7
• DOI: 10.1002/pi.5282
• Languages: English
• ISSNs: 0959-8103

Abstract

Abstract: Microbial polyhydroxyalkanoates (PHAs) have been a subject of significant research interest in the past few decades. The recent development of novel functionalized PHAs has opened up new possibilities to combine the good biocompatibility of PHA‐based drug delivery systems to, for example, improve drug loading and release properties, targeting or imaging functionalities. This mini‐review presents some recent scientific developments in the preparation of functionalized PHAs, PHA–drug and PHA–protein conjugates, multifunctional PHA nanoparticles and micelles as well as biosynthetic PHA particles for drug delivery. These developments in combination with the generally excellent biocompatibility of PHA materials are expected to further expand the interest in PHA materials for drug delivery and other therapeutic applications. © 2016 Society of Chemical Industry Abstract : Progress in the preparation of functionalized polyhydroxyalkanoates (PHAs), PHA–drug and PHA–protein conjugates, and multifunctional PHA nanoparticles and micelles has opened up new avenues for PHA‐based drug delivery systems.