Hyaluronic acid and beta cyclodextrins films for the release of corneal epithelial cells and dexamethasone. (15th June 2017)

• Record Type: Journal Article
• Authors: Fiorica, Calogero; Palumbo, Fabio Salvatore; Pitarresi, Giovanna; Bongiovì, Flavia; Giammona, Gaetano
• Is Part Of: Carbohydrate polymers. Volume 166(2017)
• Page Start: 281
• Page End: 290
• Publication Date: 2017-06-15
• Subjects: Hyaluronic acid hydrogels -- Corneal wounds -- Dexamethasone -- Cell release systems; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2017.02.071
• Languages: English
• ISSNs: 0144-8617

Abstract

Highlights: Production a novel derivative of β-cyclodextrins. Chemical crosslinking between hyaluronic acid and β-cyclodextrins derivatives. Devices able to release both corneal epithelial cells and dexamethasone. Abstract: In this work we prepared hydrogels based on hyaluronic acid and β-cyclodextrins to sustain the release of both corneal epithelial cells and dexamethasone. This steroid is administered as eye drops several times per day to reduce the risk of rejection in the post operative period after the cornea transplantation and cell release techniques. Hydrogels were produced by crosslinking an amino derivative of hyaluronic acid, with the divinyl sulfone derivative of β-cyclodextrins, this last employed as a crosslinker and solubilizing agent. Drug release studies revealed that dexamethasone containing samples are able to extend the release of this drug for at least five days. Biological studies, conducted with human corneal epithelial cells, showed that it is possible to employ the hydrogels for the temporary seeding of the cells and their potential release onto the cornea.