Synthesis and antimicrobial properties of Zn-mineralized alginate nanocomposites. (1st June 2017)

• Record Type: Journal Article
• Authors: Malagurski, Ivana; Levic, Steva; Pantic, Milena; Matijasevic, Danka; Mitric, Miodrag; Pavlovic, Vladimir; Dimitrijevic-Brankovic, Suzana
• Is Part Of: Carbohydrate polymers. Volume 165(2017)
• Page Start: 313
• Page End: 321
• Publication Date: 2017-06-01
• Subjects: Zinc -- Alginate -- Nanocomposite -- Biomineralization -- Antimicrobial activity; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2017.02.064
• Languages: English
• ISSNs: 0144-8617

Abstract

Highlights: Zn-mineralized alginate nanocomposites were produced in one-step method. Presence of Zn-mineral phase has increased total nanocomposite Zn(II) content. Stability and Zn(II) release are modulated by the presence of mineral phase. Nanocomposites release Zn(II) inducing strong antimicrobial effect. Abstract: New bioactive and antimicrobial biomaterials were produced by alginate-mediated biomineralization with Zn-mineral phase. The synthesis procedure is simple, cost-effective and resulted in two different Zn-mineralized alginate nanocomposites, Zn-carbonate/Zn-alginate and Zn-phosphate/Zn-alginate. The presence of Zn-mineral phase and its type, have significantly affected nanocomposite morphology, stability, total metallic loading and potential to release Zn(II) in physiological environment. Antimicrobial experiments showed that both types of Zn-mineralized nanocomposites exhibit strong antimicrobial effect against Escherichia coli, Staphylococcus aureus and C andida albicans. These results suggest that alginate biomineralization, where minerals are salts of essential metallic ions like Zn(II), represents a good strategy for designing multifunctional biomaterials for potential biomedical applications.