Hollow hyaluronic acid particles by competition between adhesive and cohesive properties of catechol for anticancer drug carrier. (15th May 2017)

• Record Type: Journal Article
• Authors: Lee, Jeongwook; Yoo, Ki Chun; Ko, Jaehyoung; Yoo, Bowon; Shin, Joohuei; Lee, Su-Jae; Sohn, Daewon
• Is Part Of: Carbohydrate polymers. Volume 164(2017)
• Page Start: 309
• Page End: 316
• Publication Date: 2017-05-15
• Subjects: Hyaluronic acid -- Catechol -- Redox transition -- Adhesive -- pH triggered release; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2017.02.009
• Languages: English
• ISSNs: 0144-8617

Abstract

Graphical abstract: Highlights: Catechol modified hyaluronic acid (HA-CA) shell was fabricated for drug carrier. Redox transition of catechol with pH is a key to modulate behavior of HA-CA shell. DOX loaded HA-CA particles show pH-triggered release behavior and cytotoxic effect. Abstract: The marine mussel-inspired properties of catechol, adhesiveness and cohesiveness, have been applied with pH control to fabricate hollow particles using a silica core and catechol-modified hyaluronic acid (HA-CA) shell for an anticancer drug carrier. The competition between adhesive and cohesive properties of catechol with different pH values leads to various structures, a rough catechol modified HA (HA-CA) shell at pH 5.5, monodisperse spherical silica@HA-CA particles at pH 7.4, and an amorphous HA-CA layer at pH 8.5. The redox transition of catechol with pH is a key factor modulating the behavior of the HA-CA shell on the silica core, which induces strong adhesion of HA-CA to silica at pH 5.5 and structural hardness with cohesive coupling at pH 7.4. In addition, after core removal, the hollow HA-CA particles are followed by loading of anticancer drug, doxorubicin (DOX). DOX loaded HA-CA particles show pH-triggered release behavior and dramatic cytotoxic effect indicating that they are a promising novel anticancer drug carrier.