Full‐length genomic sequence analysis of new subtype 3k hepatitis E virus isolates with 99.97% nucleotide identity obtained from two consecutive acute hepatitis patients in a city in northeast Japan. Issue 6 (26th December 2016)

• Record Type: Journal Article
• Authors: Miura, Masahito; Inoue, Jun; Tsuruoka, Mio; Nishizawa, Tsutomu; Nagashima, Shigeo; Takahashi, Masaharu; Shimosegawa, Tooru; Okamoto, Hiroaki
• Is Part Of: Journal of medical virology. Volume 89:Issue 6(2017)
• Page Start: 1116
• Page End: 1120
• Publication Date: 2016-12-26
• Subjects: full genome -- genotype 3 -- hepatitis viruses -- phylogenetic analysis -- subtype classification; Virology -- Periodicals; 616
• DOI: 10.1002/jmv.24743
• Languages: English
• ISSNs: 0146-6615

Abstract

Abstract : Full‐length genomic sequences of hepatitis E virus (HEV) obtained from two consecutive cases of acute self‐limiting hepatitis E in a city in northeast Japan were determined. Interestingly, two HEV isolates from each patient shared nucleotide identity of 99.97% in 7 225 nucleotides, and a phylogenetic analysis showed that they formed a cluster of Japanese isolates that is considered as a new HEV subtype 3k. The high similarity of HEV sequences of two isolates from these patients in this study suggested that a subtype 3k HEV strain had spread via a commonly distributed food in the city, possibly pig liver.